Evidence-based evaluation of magnetic resonance imaging as a diagnostic tool in dementia workup

Research output: Contribution to journalReview article


title = "Evidence-based evaluation of magnetic resonance imaging as a diagnostic tool in dementia workup",
abstract = "BACKGROUND: The diagnostic utility of magnetic resonance imaging in dementia workups has increased recently. The basic use is to exclude space-occupying processes in the brain. However, magnetic resonance imaging offers major opportunities for studying atrophy of specific brain areas. A great interest has been put in whether atrophy in the medial temporal lobe can serve as an early diagnostic marker for Alzheimer disease. METHODS AND RESULTS: In this evaluation, we used evidence-based techniques and reviewed more than 400 articles that address this issue. Our main finding is that a variety of methods in studying brain areas were used, and this made it difficult to extract conclusive information in a systematic way. CONCLUSION: However, we were able to conclude that atrophy of the hippocampus can distinguish patients with Alzheimer disease from healthy subjects, but there was a lack of evidence because of insufficient studies concerning the usefulness of medial temporal lobe atrophy as a diagnostic marker in a more general setting.",
keywords = "Dementia workup, medial temporal lobe, Alzheimer disease, specificity, sensitivity, likelihood ratios, evidence-based medicine, magnetic resonance imaging, diagnosis",
author = "Lars-Olof Wahlund and Ove Almkvist and Kaj Blennow and Knut Engedahl and Aki Johanson and Gunhild Waldemar and Henrike Wolf",
note = "PMID: 17088692 [PubMed - indexed for MEDLINE]",
year = "2005",
doi = "10.1097/01.rmr.0000245463.36148.12",
language = "English",
volume = "16",
pages = "427--437",
journal = "Topics in Magnetic Resonance Imaging",
issn = "0899-3459",
publisher = "Lippincott Williams & Wilkins",
number = "6",