Evidence-based evaluation of magnetic resonance imaging as a diagnostic tool in dementia workup

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Evidence-based evaluation of magnetic resonance imaging as a diagnostic tool in dementia workup. / Wahlund, Lars-Olof; Almkvist, Ove; Blennow, Kaj; Engedahl, Knut; Johanson, Aki; Waldemar, Gunhild; Wolf, Henrike.

In: Topics in Magnetic Resonance Imaging, Vol. 16, No. 6, 2005, p. 427-437.

Research output: Contribution to journalReview article

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Wahlund, Lars-Olof ; Almkvist, Ove ; Blennow, Kaj ; Engedahl, Knut ; Johanson, Aki ; Waldemar, Gunhild ; Wolf, Henrike. / Evidence-based evaluation of magnetic resonance imaging as a diagnostic tool in dementia workup. In: Topics in Magnetic Resonance Imaging. 2005 ; Vol. 16, No. 6. pp. 427-437.

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TY - JOUR

T1 - Evidence-based evaluation of magnetic resonance imaging as a diagnostic tool in dementia workup

AU - Wahlund, Lars-Olof

AU - Almkvist, Ove

AU - Blennow, Kaj

AU - Engedahl, Knut

AU - Johanson, Aki

AU - Waldemar, Gunhild

AU - Wolf, Henrike

N1 - PMID: 17088692 [PubMed - indexed for MEDLINE]

PY - 2005

Y1 - 2005

N2 - BACKGROUND: The diagnostic utility of magnetic resonance imaging in dementia workups has increased recently. The basic use is to exclude space-occupying processes in the brain. However, magnetic resonance imaging offers major opportunities for studying atrophy of specific brain areas. A great interest has been put in whether atrophy in the medial temporal lobe can serve as an early diagnostic marker for Alzheimer disease. METHODS AND RESULTS: In this evaluation, we used evidence-based techniques and reviewed more than 400 articles that address this issue. Our main finding is that a variety of methods in studying brain areas were used, and this made it difficult to extract conclusive information in a systematic way. CONCLUSION: However, we were able to conclude that atrophy of the hippocampus can distinguish patients with Alzheimer disease from healthy subjects, but there was a lack of evidence because of insufficient studies concerning the usefulness of medial temporal lobe atrophy as a diagnostic marker in a more general setting.

AB - BACKGROUND: The diagnostic utility of magnetic resonance imaging in dementia workups has increased recently. The basic use is to exclude space-occupying processes in the brain. However, magnetic resonance imaging offers major opportunities for studying atrophy of specific brain areas. A great interest has been put in whether atrophy in the medial temporal lobe can serve as an early diagnostic marker for Alzheimer disease. METHODS AND RESULTS: In this evaluation, we used evidence-based techniques and reviewed more than 400 articles that address this issue. Our main finding is that a variety of methods in studying brain areas were used, and this made it difficult to extract conclusive information in a systematic way. CONCLUSION: However, we were able to conclude that atrophy of the hippocampus can distinguish patients with Alzheimer disease from healthy subjects, but there was a lack of evidence because of insufficient studies concerning the usefulness of medial temporal lobe atrophy as a diagnostic marker in a more general setting.

KW - Dementia workup

KW - medial temporal lobe

KW - Alzheimer disease

KW - specificity

KW - sensitivity

KW - likelihood ratios

KW - evidence-based medicine

KW - magnetic resonance imaging

KW - diagnosis

U2 - 10.1097/01.rmr.0000245463.36148.12

DO - 10.1097/01.rmr.0000245463.36148.12

M3 - Review article

VL - 16

SP - 427

EP - 437

JO - Topics in Magnetic Resonance Imaging

T2 - Topics in Magnetic Resonance Imaging

JF - Topics in Magnetic Resonance Imaging

SN - 0899-3459

IS - 6

ER -