Exosomes in Parkinson's Disease: Current Perspectives and Future Challenges

Research output: Contribution to journalArticle

Abstract

Exosomes, which are lipid bilayer membrane vesicles, have been implicated as carriers of biological macromolecules. In recent years, the functions of exosomes in the spreading of pathological conversion of proteins among neurons have drawn particular attention in Parkinson's disease research. Extracellular α-synuclein is proven to be associated with exosomes in vivo and in vitro. The contents of these exosomes may be altered during the pathological and clinical processes, serving as a potential target for biomarker development in Parkinson's disease. This Review highlights the current understanding of biogenesis and pathophysiological roles of exosomes. Meanwhile, exosomes are promising delivery vehicles. Artificial exosomes can be loaded with defined therapeutically active molecules, such as drugs, small interfering RNAs, long noncoding RNAs, and proteins to the brain, ensuring the site-specific targeting strategy to the recipient cells. Therefore, we will also discuss the potential applications of exosomes in developing modified exosome-based drug carrier systems to halt the pathologic propagation of Parkinson's disease.

Details

Authors
Organisations
External organisations
  • China Medical University, Shenyang
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
  • Medicinal Chemistry

Keywords

  • Exosomes, Parkinson's disease, α-synuclein
Original languageEnglish
Pages (from-to)964–972
JournalACS Chemical Neuroscience
Volume10
Issue number2
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes