Experimental results from a preclinical X-ray phase-contrast CT scanner

Research output: Contribution to journalArticle

Abstract

To explore the future clinical potential of improved soft-tissue visibility with grating-based X-ray phase contrast (PC), we have developed a first preclinical computed tomography (CT) scanner featuring a rotating gantry. The main challenge in the transition from previous bench-top systems to a preclinical scanner are phase artifacts that are caused by minimal changes in the grating alignment during gantry rotation. In this paper, we present the first experimental results from the system together with an adaptive phase recovery method that corrects for these phase artifacts. Using this method, we show that the scanner can recover quantitatively accurate Hounsfield units in attenuation and phase. Moreover, we present a first tomography scan of biological tissue with complementary information in attenuation and phase contrast. The present study hence demonstrates the feasibility of grating-based phase contrast with a rotating gantry for the first time and paves the way for future in vivo studies on small animal disease models (in the mid-term future) and human diagnostics applications (in the long-term future).

Details

Authors
  • Arne Tapfer
  • Martin Bech
  • Astrid Velroyen
  • Jan Meiser
  • Juergen Mohr
  • Marco Walter
  • Joachim Schulz
  • Bart Pauwels
  • Peter Bruyndonckx
  • Xuan Liu
  • Alexander Sasov
  • Franz Pfeiffer
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Radiology, Nuclear Medicine and Medical Imaging

Keywords

  • differential X-ray phase contrast, grating interferometer, X-ray imaging
Original languageEnglish
Pages (from-to)15691-15696
JournalProceedings of the National Academy of Sciences
Volume109
Issue number39
Publication statusPublished - 2012
Publication categoryResearch
Peer-reviewedYes