Exploring the multifaceted nature of the common lymphoid progenitor compartment.

Research output: Contribution to journalReview article

Abstract

While the common lymphoid progenitor compartment was originally thought to be a rather homogenous cell population, it has become increasingly clear that this compartment is highly heterogeneous both with regard to phenotypic and functional features. The exploration of this cellular complexity has generated novel molecular insights into regulatory events in lymphoid lineage restriction and provided support for the idea that multiple lineage restriction events occur at this developmental stage. Furthermore, the identification of multiple lineage-restricted progenitors with mixed lineage potential challenges a strictly hierarchical model for lymphoid development. Instead we propose a model based on competence windows during which cell fates are established through the action of lineage determining factors.

Details

Authors
Organisations
External organisations
  • Linköping University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Developmental Biology
  • Cell and Molecular Biology
Original languageEnglish
Pages (from-to)121-126
JournalCurrent Opinion in Immunology
Volume39
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes