Exposure to inorganic arsenic and gene expression in peripheral blood

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

Abstract

Arsenic is an established carcinogen and a risk factor for several non-malignant diseases. Mechanisms of arsenic toxicity may include interference with gene expression. The impact of arsenic exposure on gene expression was evaluated in women (n = 80) living in the Puna of the northern Argentinian Andes with varying concentrations (10–1251 μg/L) of arsenic in drinking water. DirectHyb HumanHT-12 v4.0 was used for genome wide gene expression analysis. Robust linear regression model was used to each array to evaluate the relations between arsenic exposure, gene expression and with the influence of arsenic metabolism efficiency. Also, Ingenuity Pathway Analysis (IPA) was performed to look for relevant pathways, diseases, networks etc. associated with the genes. In the association between arsenic and gene expression, most of the genes were downregu-lated. Pathway analyses revealed different expression pattern associated with arsenic exposure between women with high and low urinary %MMA, indicating variation in arsenic susceptibility by arsenic-methylation.

Details

Authors
Organisations
External organisations
  • Karolinska Institutet
  • National Food Agency
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Environmental Health and Occupational Health
Original languageEnglish
Title of host publicationArsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
PublisherCRC Press/Balkema
Pages448-449
Number of pages2
ISBN (Print)9781138029415
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes
Event6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, Sweden
Duration: 2016 Jun 192016 Jun 23

Conference

Conference6th International Congress on Arsenic in the Environment, AS 2016
CountrySweden
CityStockholm
Period2016/06/192016/06/23