Exposure to inorganic arsenic and mitochondrial DNA copy number and telomere length in peripheral blood

Research output: Chapter in Book/Report/Conference proceedingPaper in conference proceeding

Abstract

Exposure to inorganic arsenic (iAs) is a risk factor for cancer. Alterations in mitochondrial DNA copy number (mtDNAcn) and telomere length (TL) have been associated with cancer risk. Two Argentinean groups were studied: A) Puna area of Andes and B) Chaco. Arsenic exposure was assessed as the sum of arsenic metabolites (iAs, MMA, and DMA) in urine (U-As) using HPLC-HG-ICPMS. MtDNAcn, TL, and genotype of the arsenic-methylating gene AS3MT were determined in blood by real-timePCR. The Chaco participants had less-efficient metabolism, with higher%iAs and%MMA in urine, and lower frequency of the efficient-metabolizing AS3MT haplotype. U-As was associated with increased mtDNAcn in Chaco but not in Andes. U-As was associated with longer TL in Chaco, but less so in Andes. Individuals with%iAs>median showed significantly higher mtDNAcn and TL in both groups. Arsenic was associated with increased mtDNAcn and TL, particularly in individuals with less-efficient arsenic metabolism, who might have increased risk for arsenic-related cancer.

Details

Authors
  • S. S. Ameer
  • Y. Y. Xu
  • K. Engström
  • H. Li
  • P. Tallving
  • P. Boemo
  • L A Parada
  • L. Guadalupe Peñaloza
  • Gabriela Concha
  • Florencia Harari
  • M Vahter
  • K. Broberg
Organisations
External organisations
  • National Food Agency
  • Karolinska Institutet
  • National University of Salta
  • National Scientific and Technical Research Council, Argentina
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Environmental Health and Occupational Health
  • Medical Genetics
Original languageEnglish
Title of host publicationArsenic Research and Global Sustainability - Proceedings of the 6th International Congress on Arsenic in the Environment, AS 2016
PublisherCRC Press/Balkema
Pages450-452
Number of pages3
ISBN (Print)9781138029415
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes
Event6th International Congress on Arsenic in the Environment, AS 2016 - Stockholm, Sweden
Duration: 2016 Jun 192016 Jun 23

Conference

Conference6th International Congress on Arsenic in the Environment, AS 2016
CountrySweden
CityStockholm
Period2016/06/192016/06/23