Expression of functional toll like receptor 4 in estrogen receptor/progesterone receptor-negative breast cancer.

Research output: Contribution to journalArticle

Abstract

Toll-like receptors (TLRs) are a family of pattern recognition receptors that are expressed on cells of the innate immune system. The ligands can be pathogen derived (pathogen associated molecular patterns; PAMPs) or endogenous (damage associated molecular patters; DAMPs) that when bound induces activation of nuclear factor kappa B (NF-κB) and transcription of pro-inflammatory genes. TLRs have also been discovered in various malignant cell types, but with unknown function.

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Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Article number130
JournalBreast Cancer Research
Volume17
Issue number1
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Cancer immunology (013031800), Clinical pathology, Malmö (013017551), Experimental Infection Medicine (013017505), Faculty of Medicine (000022000), Oncology, MV (013035000), Pathology, (Lund) (013030000)

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