Expression of interleukin-15 in mouse and human atherosclerotic lesions

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Expression of interleukin-15 in mouse and human atherosclerotic lesions. / Wuttge, Dirk; Eriksson, Per; Sirsjo, Allan; Hansson, Göran K.; Stemme, Sten.

In: American Journal of Pathology, Vol. 159, No. 2, 2001, p. 417-423.

Research output: Contribution to journalArticle

Harvard

Wuttge, D, Eriksson, P, Sirsjo, A, Hansson, GK & Stemme, S 2001, 'Expression of interleukin-15 in mouse and human atherosclerotic lesions', American Journal of Pathology, vol. 159, no. 2, pp. 417-423.

APA

Wuttge, D., Eriksson, P., Sirsjo, A., Hansson, G. K., & Stemme, S. (2001). Expression of interleukin-15 in mouse and human atherosclerotic lesions. American Journal of Pathology, 159(2), 417-423.

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MLA

Vancouver

Author

Wuttge, Dirk ; Eriksson, Per ; Sirsjo, Allan ; Hansson, Göran K. ; Stemme, Sten. / Expression of interleukin-15 in mouse and human atherosclerotic lesions. In: American Journal of Pathology. 2001 ; Vol. 159, No. 2. pp. 417-423.

RIS

TY - JOUR

T1 - Expression of interleukin-15 in mouse and human atherosclerotic lesions

AU - Wuttge, Dirk

AU - Eriksson, Per

AU - Sirsjo, Allan

AU - Hansson, Göran K.

AU - Stemme, Sten

PY - 2001

Y1 - 2001

N2 - Atherosclerotic lesions are characterized by prominent macrophage and T-cell infiltration and atherosclerosis is widely recognized as an inflammatory disease. The cytokine interleukin-15 (IL-15) has T-cell chemotactic and pro-inflammatory properties and promotes the recruitment of T cells to sites of inflammation. We have therefore examined IL-15 expression in the atherosclerotic ApoE-deficient mouse model as well as in human atherosclerotic lesions. In gene expression arrays, a transcript corresponding to IL-15 mRNA was elevated in atherosclerotic aortas of ApoE-deficient mice fed a Western diet for 10 and 20 weeks, corresponding to lesions of the fatty streak and fibrofatty plaque stage, respectively. Immunostaining for IL-15 localized to aortic smooth muscle cells in nonatherosclerotic C57BL/6 mice, whereas both macrophages and smooth muscle cells stained positive for IL-15 in atherosclerotic lesions of ApoE-deficient mice. Finally, advanced atherosclerotic lesions of human carotid arteries were immunostained to determine whether IL-15 is involved in human disease. IL-15 protein was present also in the human lesions with a distribution primarily overlapping that of macrophages. In conclusion, IL-15 is up-regulated in both human and animal atherosclerotic lesions and may contribute to the recruitment of T cells and their activation during atherogenesis.

AB - Atherosclerotic lesions are characterized by prominent macrophage and T-cell infiltration and atherosclerosis is widely recognized as an inflammatory disease. The cytokine interleukin-15 (IL-15) has T-cell chemotactic and pro-inflammatory properties and promotes the recruitment of T cells to sites of inflammation. We have therefore examined IL-15 expression in the atherosclerotic ApoE-deficient mouse model as well as in human atherosclerotic lesions. In gene expression arrays, a transcript corresponding to IL-15 mRNA was elevated in atherosclerotic aortas of ApoE-deficient mice fed a Western diet for 10 and 20 weeks, corresponding to lesions of the fatty streak and fibrofatty plaque stage, respectively. Immunostaining for IL-15 localized to aortic smooth muscle cells in nonatherosclerotic C57BL/6 mice, whereas both macrophages and smooth muscle cells stained positive for IL-15 in atherosclerotic lesions of ApoE-deficient mice. Finally, advanced atherosclerotic lesions of human carotid arteries were immunostained to determine whether IL-15 is involved in human disease. IL-15 protein was present also in the human lesions with a distribution primarily overlapping that of macrophages. In conclusion, IL-15 is up-regulated in both human and animal atherosclerotic lesions and may contribute to the recruitment of T cells and their activation during atherogenesis.

M3 - Article

VL - 159

SP - 417

EP - 423

JO - American Journal of Pathology

JF - American Journal of Pathology

SN - 1525-2191

IS - 2

ER -