Expression of the IFN-inducible p53-target gene TRIM22 is down-regulated during erythroid differentiation of human bone marrow.

Research output: Contribution to journalArticle

Standard

Harvard

APA

CBE

MLA

Vancouver

Author

RIS

TY - JOUR

T1 - Expression of the IFN-inducible p53-target gene TRIM22 is down-regulated during erythroid differentiation of human bone marrow.

AU - Obad, Susanna

AU - Olofsson, Tor

AU - Mechti, Nadir

AU - Gullberg, Urban

AU - Drott, Kristina

PY - 2007

Y1 - 2007

N2 - The interferon inducible protein TRIM22 has been identified as a p53 target gene, with possible involvement in proliferation and differentiation of leukaemia cells. Here, the expression levels of TRIM22 during haematopoietic differentiation are characterised. Expression of TRIM22 correlates inversely to differentiation, as TRIM22 is highly expressed in CD34(+) human bone marrow progenitor cells, but declines in mature populations. The erythroid lineage appears as a special case, as TRIM22 expression shows an extreme decrease during late erythroid maturation and is completely undetectable in nucleated erythroid populations in contrast to other lineages. In conclusion, our data Could suggest lineage-specific roles for TRIM22 during haematopoietic differentiation.

AB - The interferon inducible protein TRIM22 has been identified as a p53 target gene, with possible involvement in proliferation and differentiation of leukaemia cells. Here, the expression levels of TRIM22 during haematopoietic differentiation are characterised. Expression of TRIM22 correlates inversely to differentiation, as TRIM22 is highly expressed in CD34(+) human bone marrow progenitor cells, but declines in mature populations. The erythroid lineage appears as a special case, as TRIM22 expression shows an extreme decrease during late erythroid maturation and is completely undetectable in nucleated erythroid populations in contrast to other lineages. In conclusion, our data Could suggest lineage-specific roles for TRIM22 during haematopoietic differentiation.

KW - IFN

KW - differentiation

KW - p53

KW - haematopoiesis

KW - TRIM22

KW - Staf50

U2 - 10.1016/j.leukres.2006.12.012

DO - 10.1016/j.leukres.2006.12.012

M3 - Article

VL - 31

SP - 995

EP - 1001

JO - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

T2 - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

JF - Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis

SN - 1873-5835

IS - 7

ER -