Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models.

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Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models. / Liedberg, Ann-Sofie; Lu, Shemin; Holmdahl, Rikard.

In: Clinical and Experimental Immunology, Vol. 127, No. 1, 2002, p. 37-42.

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Liedberg, Ann-Sofie ; Lu, Shemin ; Holmdahl, Rikard. / Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models. In: Clinical and Experimental Immunology. 2002 ; Vol. 127, No. 1. pp. 37-42.

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TY - JOUR

T1 - Extra-articular cartilage affected in collagen-induced, but not pristane-induced, arthritis models.

AU - Liedberg, Ann-Sofie

AU - Lu, Shemin

AU - Holmdahl, Rikard

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019), Division of Microbiology, Immunology and Glycobiology - MIG (013025200)

PY - 2002

Y1 - 2002

N2 - Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting cartilaginous joints but also extra-articular tissues such as the nose and upper respiratory tract. We have investigated extra-articular cartilage involvement in two commonly used animal models for RA, collagen-induced and pristane-induced arthritis, by immunizing rats with different susceptibility to disease (LEW.1 A, LEW.1F and DA rats). We found that nasal and tracheolaryngeal cartilage is affected in LEW.1 A and DA rats to varying degrees in collagen-induced arthritis but not in any strain in the pristane-induced model. Antibodies to matrilin-1, a cartilage-specific protein expressed mainly in tracheolaryngeal and nasal cartilage but not in joints, were positively associated with the presence of inflammation in nasal cartilage. In contrast, no antibody response to matrilin-1 could be detected in pristane-induced arthritis. In addition, nasal vaccination with collagen type II prior to immunization in DA rats significantly decreased the antibody response to matrilin-1 at day 56, but not at earlier time points, indicating a late protective effect on extra-articular cartilage. We conclude that pristane-induced arthritis is a joint-specific model whereas collagen-induced arthritis affect joints as well as extra-articular cartilage. Furthermore, collagen immunization induces an antibody response to matrilin-1.

AB - Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting cartilaginous joints but also extra-articular tissues such as the nose and upper respiratory tract. We have investigated extra-articular cartilage involvement in two commonly used animal models for RA, collagen-induced and pristane-induced arthritis, by immunizing rats with different susceptibility to disease (LEW.1 A, LEW.1F and DA rats). We found that nasal and tracheolaryngeal cartilage is affected in LEW.1 A and DA rats to varying degrees in collagen-induced arthritis but not in any strain in the pristane-induced model. Antibodies to matrilin-1, a cartilage-specific protein expressed mainly in tracheolaryngeal and nasal cartilage but not in joints, were positively associated with the presence of inflammation in nasal cartilage. In contrast, no antibody response to matrilin-1 could be detected in pristane-induced arthritis. In addition, nasal vaccination with collagen type II prior to immunization in DA rats significantly decreased the antibody response to matrilin-1 at day 56, but not at earlier time points, indicating a late protective effect on extra-articular cartilage. We conclude that pristane-induced arthritis is a joint-specific model whereas collagen-induced arthritis affect joints as well as extra-articular cartilage. Furthermore, collagen immunization induces an antibody response to matrilin-1.

KW - Collagen/immunology

KW - Disease Susceptibility

KW - Extracellular Matrix Proteins/immunology

KW - Glycoproteins/immunology

KW - Immunosuppressive Agents/immunology

KW - Rats

KW - Inbred Lew

KW - Species Specificity

KW - Support

KW - Non-U.S. Gov't

KW - Terpenes/immunology

KW - Articular/immunology/pathology

KW - Animal

KW - Arthritis

KW - Experimental/immunology/pathology

KW - Autoantibodies/immunology

KW - Cartilage

U2 - 10.1046/j.1365-2249.2002.01712.x

DO - 10.1046/j.1365-2249.2002.01712.x

M3 - Article

VL - 127

SP - 37

EP - 42

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 1

ER -