Extracellular signal-regulated kinase activation is required for consolidation and reconsolidation of memory at an early stage of ontogenesis

Research output: Contribution to journalArticle

Abstract

The ability to form long-term memories exists very early during ontogeny; however, the properties of early memory processes, brain structures involved and underlying cellular mechanisms are poorly defined. Here, we examine the role of extracellular signal-regulated kinase (ERK), a member of the mitogen-activated protein kinase/ERK signaling cascade, which is crucial for adult memory, in the consolidation and reconsolidation of an early memory using a conditioned taste aversion paradigm in 3-day-old rat pups. We show that intraperitoneal injection of SL327, the upstream mitogen-activated protein kinase kinase inhibitor, impairs both consolidation and reconsolidation of early memory, leaving short-term memory after acquisition and after reactivation intact. The amnesic effect of SL327 diminishes with increasing delays after acquisition and reactivation. Biochemical analyses revealed ERK hyperphosphorylation in the amygdala but not the hippocampus following acquisition, suggesting functional activation of the amygdala as early as post-natal day 3, although there was no clear evidence for amygdalar ERK activation after reactivation. These results indicate that, despite an immature brain, the basic properties of memory and at least some of the molecular mechanisms and brain structures implicated in aversion memory share a number of similarities with the adult and emerge very early during ontogeny.

Details

Authors
  • Solène Languille
  • Sabrina Davis
  • Paulette Richer
  • Cristina Alcacer
  • Serge Laroche
  • Bernard Hars
External organisations
  • University of Paris-Sud
  • Centre d'Ecologie Fonctionnelle et Evolutive (CEFE)
Research areas and keywords

Keywords

  • Amygdala, Aversive conditioning, Memory formation, Mitogen-activated protein kinase, Neonatal rat
Original languageEnglish
Pages (from-to)1923-1930
Number of pages8
JournalEuropean Journal of Neuroscience
Volume30
Issue number10
Publication statusPublished - 2009 Nov
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes