Extreme sleep pattern in Lewy body dementia: A hypothalamic matter?

Research output: Contribution to journalArticle

Abstract

Excessive sleep during the night and for >2 hours during the day is part of the fluctuating wakefulness criterion of dementia with Lewy bodies (DLB). The phenomenon â € sleep days' is not uncommon in nursing homes. Here, we describe a woman who, for months, slept for 3 days and nights in a row and thereafter was awake for 3 days and nights. Electroencephalogram (EEG) showed slow background activity and increased delta activity. No epileptiform activity was detected. Polysomnography showed a severely disturbed, markedly fragmented sleep pattern. On her death, neuropathology revealed degeneration and loss of neurons along with α-synuclein-containing Lewy body inclusions and neurites in the substantia nigra, locus coeruleus, hypothalamus, and neocortex, thus fulfilling the criteria of DLB, cortical type. We propose that the hypothalamic degeneration contributed significantly to the clinical profile in this case. We suggest that patients with sleep days should be investigated for other DLB signs.

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Authors
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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • memory disorders, sleep disorders (neurology)
Original languageEnglish
Article numbere228177
JournalBMJ Case Reports
Volume12
Issue number3
Publication statusPublished - 2019
Publication categoryResearch
Peer-reviewedYes