Fabrication of sample target plate for MALDI-TOF MS using proton beam writing

Research output: Contribution to journalArticle

Abstract

Ion beam irradiation of silicon followed by electrochemical etching has been used to produce fluid anchor points on a sample target plate for matrix assisted laser desorption ionization mass spectrometry. Non-porous areas on the fabricated target plate serve as anchor points for sample deposition. High hydrophobicity of the macroporous silicon surface surrounding anchor points intrinsically led to a better sample confinement and gave the possibility to deposit large volumes of sample at predefined spot areas, improving the sensitivity in bioanalyte readout. We also have found that irradiation with beam fluences lower than 1014 cm−2 led to the enhanced anodization rate producing inverse structures.

Details

Authors
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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Engineering

Keywords

  • MALDI-TOF MS analysis, Anchor chip, Sample target, Superhydrophobic surface, Porous silicon, Proton beam writing
Original languageEnglish
Pages (from-to)715-718
JournalNuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
Volume249
Issue number1-2
Publication statusPublished - 2006
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007), Analytical Chemistry (S/LTH) (011001004), Biomedical Engineering (011200011)