Factor XIII and tissue transglutaminase antibodies in coeliac and inflammatory bowel disease.

Research output: Contribution to journalArticle

Abstract

issue transglutaminase (tTg) has been identified as an autoantigen in coeliac disease (CD). There is a marked homology between different forms of transglutaminase, such as tTg and coagulation factor XIII. We compared titres of both IgA- and IgG-antibodies against these two antigens in 20 CD patients, 20 endomysial antibody (EMA)-negative controls and a group with inflammatory bowel disease (34 with Crohn's disease and 23 with ulcerative colitis). IgA-antibodies against tTg correlated with EMA titres and had high sensitivity and specificity in screening for CD. Only in two CD patients were high titres found of IgA-antibodies against factor XIII, non-reactive with tTg. Both lacked bleeding tendency. The presence of IgG-antibodies against tTg, in contrast, had low sensitivity and specificity in screening for CD and were frequently seen in inflammatory bowel disease. Similarly, factor XIII IgG-antibodies displayed a non-specific pattern with modestly elevated titres in patients with Crohn's disease and in both EMA-negative and positive patients. Despite a marked homology with tTg, the occurrence of high titre IgA-antibodies against factor XIII is infrequent in CD, but may--when present--be the result of epitope spreading. The presence of IgG-antibodies in CD and inflammatory bowel disease illustrates the complexity of autoantibody reactions in gastrointestinal disease.

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Research areas and keywords

Subject classification (UKÄ)

  • Rheumatology and Autoimmunity

Keywords

  • Autoimmunity, Coeliac Disease, Endomysial Antibodies, Factor Xiii, Transglutaminase Antibodies
Original languageEnglish
Pages (from-to)357-364
JournalAutoimmunity
Volume35
Issue number5
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes