Familial risk of sleep-disordered breathing

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Bibtex

@article{977ded8fabe447fdbaebe6278d525acf,
title = "Familial risk of sleep-disordered breathing",
abstract = "Objective: To estimate the incidence of hospitalization for paediatric obstructive sleep apnoea syndrome (OSAS) or sleep-disordered breathing (SDB) caused by adenotonsillar or tonsillar hypertrophy without infection in children with a parent affected by OSAS. Patients and methods: Using the MigMed database at Lund University, hospital data on all children aged 0-18 years in Sweden between 1997 and 2007 (total of 3 million individuals) were used to identify all first hospital admissions for OSAS or either adenotonsillar or tonsillar hypertrophy. Next, individuals were categorized as either having or not having a parent affected by OSAS. Standardized incidence ratios (SIRs) with 95{\%} confidence intervals (CIs) were estimated for boys and girls with a parent affected by OSAS. Children with OSAS or adenotonsillar or tonsillar hypertrophy without a parent affected by OSAS acted as the reference group (SIR = 1). Results: After accounting for socio-economic status, age, and geographic region, the SIRs of OSAS in boys and girls with a parent affected by OSAS were 3.09 (95{\%} CI 1.83-4.90) and 4.46 (95{\%} CI 2.68-6.98), respectively. The SIRs of adenotonsillar or tonsillar hypertrophy in boys and girls with a parent affected by OSAS were 1.82 (95{\%} CI 1.54-2.14) and 1.56 (95{\%} CI 1.30-1.87), respectively. Conclusion: This study indicates familial clustering of sleep-disordered breathing, which is important information for clinicians. (C) 2012 Elsevier B.V. All rights reserved.",
keywords = "Adenotonsillar hypertrophy, Children, Heredity, Hospitalization, Obstructive sleep apnoea, Population-based studies, Sleep-disordered, breathing",
author = "Karin Lundkvist and Kristina Sundquist and Xinjun Li and Danielle Friberg",
year = "2012",
doi = "10.1016/j.sleep.2012.01.014",
language = "English",
volume = "13",
pages = "668--673",
journal = "Sleep Medicine",
issn = "1878-5506",
publisher = "Elsevier",
number = "6",

}