Familial risk of sleep-disordered breathing

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Familial risk of sleep-disordered breathing. / Lundkvist, Karin; Sundquist, Kristina; Li, Xinjun; Friberg, Danielle.

In: Sleep Medicine, Vol. 13, No. 6, 2012, p. 668-673.

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Lundkvist, Karin ; Sundquist, Kristina ; Li, Xinjun ; Friberg, Danielle. / Familial risk of sleep-disordered breathing. In: Sleep Medicine. 2012 ; Vol. 13, No. 6. pp. 668-673.

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TY - JOUR

T1 - Familial risk of sleep-disordered breathing

AU - Lundkvist, Karin

AU - Sundquist, Kristina

AU - Li, Xinjun

AU - Friberg, Danielle

PY - 2012

Y1 - 2012

N2 - Objective: To estimate the incidence of hospitalization for paediatric obstructive sleep apnoea syndrome (OSAS) or sleep-disordered breathing (SDB) caused by adenotonsillar or tonsillar hypertrophy without infection in children with a parent affected by OSAS. Patients and methods: Using the MigMed database at Lund University, hospital data on all children aged 0-18 years in Sweden between 1997 and 2007 (total of 3 million individuals) were used to identify all first hospital admissions for OSAS or either adenotonsillar or tonsillar hypertrophy. Next, individuals were categorized as either having or not having a parent affected by OSAS. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated for boys and girls with a parent affected by OSAS. Children with OSAS or adenotonsillar or tonsillar hypertrophy without a parent affected by OSAS acted as the reference group (SIR = 1). Results: After accounting for socio-economic status, age, and geographic region, the SIRs of OSAS in boys and girls with a parent affected by OSAS were 3.09 (95% CI 1.83-4.90) and 4.46 (95% CI 2.68-6.98), respectively. The SIRs of adenotonsillar or tonsillar hypertrophy in boys and girls with a parent affected by OSAS were 1.82 (95% CI 1.54-2.14) and 1.56 (95% CI 1.30-1.87), respectively. Conclusion: This study indicates familial clustering of sleep-disordered breathing, which is important information for clinicians. (C) 2012 Elsevier B.V. All rights reserved.

AB - Objective: To estimate the incidence of hospitalization for paediatric obstructive sleep apnoea syndrome (OSAS) or sleep-disordered breathing (SDB) caused by adenotonsillar or tonsillar hypertrophy without infection in children with a parent affected by OSAS. Patients and methods: Using the MigMed database at Lund University, hospital data on all children aged 0-18 years in Sweden between 1997 and 2007 (total of 3 million individuals) were used to identify all first hospital admissions for OSAS or either adenotonsillar or tonsillar hypertrophy. Next, individuals were categorized as either having or not having a parent affected by OSAS. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated for boys and girls with a parent affected by OSAS. Children with OSAS or adenotonsillar or tonsillar hypertrophy without a parent affected by OSAS acted as the reference group (SIR = 1). Results: After accounting for socio-economic status, age, and geographic region, the SIRs of OSAS in boys and girls with a parent affected by OSAS were 3.09 (95% CI 1.83-4.90) and 4.46 (95% CI 2.68-6.98), respectively. The SIRs of adenotonsillar or tonsillar hypertrophy in boys and girls with a parent affected by OSAS were 1.82 (95% CI 1.54-2.14) and 1.56 (95% CI 1.30-1.87), respectively. Conclusion: This study indicates familial clustering of sleep-disordered breathing, which is important information for clinicians. (C) 2012 Elsevier B.V. All rights reserved.

KW - Adenotonsillar hypertrophy

KW - Children

KW - Heredity

KW - Hospitalization

KW - Obstructive sleep apnoea

KW - Population-based studies

KW - Sleep-disordered

KW - breathing

U2 - 10.1016/j.sleep.2012.01.014

DO - 10.1016/j.sleep.2012.01.014

M3 - Article

VL - 13

SP - 668

EP - 673

JO - Sleep Medicine

T2 - Sleep Medicine

JF - Sleep Medicine

SN - 1878-5506

IS - 6

ER -