Familial testicular cancer in Norway and southern Sweden

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Familial testicular cancer in Norway and southern Sweden. / Heimdal, K; Olsson, Håkan; Tretli, S; Flodgren, P; Børresen, A L; Fossa, S D.

In: British Journal of Cancer, Vol. 73, No. 7, 04.1996, p. 964-9.

Research output: Contribution to journalArticle

Harvard

Heimdal, K, Olsson, H, Tretli, S, Flodgren, P, Børresen, AL & Fossa, SD 1996, 'Familial testicular cancer in Norway and southern Sweden', British Journal of Cancer, vol. 73, no. 7, pp. 964-9.

APA

Heimdal, K., Olsson, H., Tretli, S., Flodgren, P., Børresen, A. L., & Fossa, S. D. (1996). Familial testicular cancer in Norway and southern Sweden. British Journal of Cancer, 73(7), 964-9.

CBE

Heimdal K, Olsson H, Tretli S, Flodgren P, Børresen AL, Fossa SD. 1996. Familial testicular cancer in Norway and southern Sweden. British Journal of Cancer. 73(7):964-9.

MLA

Vancouver

Heimdal K, Olsson H, Tretli S, Flodgren P, Børresen AL, Fossa SD. Familial testicular cancer in Norway and southern Sweden. British Journal of Cancer. 1996 Apr;73(7):964-9.

Author

Heimdal, K ; Olsson, Håkan ; Tretli, S ; Flodgren, P ; Børresen, A L ; Fossa, S D. / Familial testicular cancer in Norway and southern Sweden. In: British Journal of Cancer. 1996 ; Vol. 73, No. 7. pp. 964-9.

RIS

TY - JOUR

T1 - Familial testicular cancer in Norway and southern Sweden

AU - Heimdal, K

AU - Olsson, Håkan

AU - Tretli, S

AU - Flodgren, P

AU - Børresen, A L

AU - Fossa, S D

PY - 1996/4

Y1 - 1996/4

N2 - Information about occurrence of testicular cancer (TC) in relatives of TC patients has been collected using questionnaires from 797 out of 922 consecutive Norwegian and 178 out of 237 Swedish patients with TC seen at the Norwegian Radium Hospital and the University Hospital Lund in Sweden during 1981-91. Fifty-one Norwegian and five Swedish patients had a relative with confirmed TC. Thus, 51/922 (5.5%) of the Norwegian and 5/237 (2.1%) of the Swedish patients treated during the time interval investigated were considered to have familial TC. Thirty-two of the patients had an affected first-degree relative. Expected numbers of cancers in the relatives were computed from data in the Norwegian and Swedish Cancer Registries. Standardised incidence ratios (SIRs) were taken as observed numbers of TC/expected numbers of TC in the relatives. The SIR for brothers was 10.2 (95% confidence interval 6.22-15.77). SIR for fathers was 4.3 (1.6-9.3) and for sons 5.7 (0.7-23.2). The point estimate for the risk to brothers in the Norwegian part of the sample to develop TC by the age of 60 was 4.1% (95% CI 1.7-6.6%). This study indicates that genetic factors may be of greater importance in TC than previously assumed. Patients with familial testicular cancer had bilateral tumours more often than sporadic cases (9.8% bilaterality in familial vs 2.8% in sporadic cases, P=0.02). For patients with seminoma age of onset was lower in familial than in sporadic cases (32.9 vs 37.6 years, P=0.06). In father-son pairs, there was a statistically significant earlier age of diagnosis in the generation of sons (28.8 years vs 44.9 years, P=0.04). The prevalence of undescended testis (UDT) did not seem to be higher in familial than in sporadic TC (8.2% in familial TC and 13.3% in sporadic cases). This may indicate that different factors are of importance for the development of familial TC and UDT.

AB - Information about occurrence of testicular cancer (TC) in relatives of TC patients has been collected using questionnaires from 797 out of 922 consecutive Norwegian and 178 out of 237 Swedish patients with TC seen at the Norwegian Radium Hospital and the University Hospital Lund in Sweden during 1981-91. Fifty-one Norwegian and five Swedish patients had a relative with confirmed TC. Thus, 51/922 (5.5%) of the Norwegian and 5/237 (2.1%) of the Swedish patients treated during the time interval investigated were considered to have familial TC. Thirty-two of the patients had an affected first-degree relative. Expected numbers of cancers in the relatives were computed from data in the Norwegian and Swedish Cancer Registries. Standardised incidence ratios (SIRs) were taken as observed numbers of TC/expected numbers of TC in the relatives. The SIR for brothers was 10.2 (95% confidence interval 6.22-15.77). SIR for fathers was 4.3 (1.6-9.3) and for sons 5.7 (0.7-23.2). The point estimate for the risk to brothers in the Norwegian part of the sample to develop TC by the age of 60 was 4.1% (95% CI 1.7-6.6%). This study indicates that genetic factors may be of greater importance in TC than previously assumed. Patients with familial testicular cancer had bilateral tumours more often than sporadic cases (9.8% bilaterality in familial vs 2.8% in sporadic cases, P=0.02). For patients with seminoma age of onset was lower in familial than in sporadic cases (32.9 vs 37.6 years, P=0.06). In father-son pairs, there was a statistically significant earlier age of diagnosis in the generation of sons (28.8 years vs 44.9 years, P=0.04). The prevalence of undescended testis (UDT) did not seem to be higher in familial than in sporadic TC (8.2% in familial TC and 13.3% in sporadic cases). This may indicate that different factors are of importance for the development of familial TC and UDT.

KW - Adolescent

KW - Adult

KW - Aged

KW - Family Health

KW - Humans

KW - Male

KW - Middle Aged

KW - Norway

KW - Pedigree

KW - Risk Factors

KW - Sweden

KW - Testicular Neoplasms

M3 - Article

VL - 73

SP - 964

EP - 969

JO - British Journal of Cancer

JF - British Journal of Cancer

SN - 1532-1827

IS - 7

ER -