Familial upper aerodigestive tract cancers: incidence trends, familial clustering and subsequent cancers

Research output: Contribution to journalArticle


Familial risks in upper aerodigestive tract cancer have been assessed mainly through case-control studies based on reported but not medically verified cancers in family members. The nationwide Swedish Family-Cancer Database was used to describe the incidence trends for all subsites of upper aerodigestive tract cancer and to calculate standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for the cancer in 0-66-year-old offspring by cancers in family members. Additionally, SIRs for second primary cancer after upper aerodigestive tract cancers were analysed. SIRs in offspring for all upper aerodigestive tract cancer were not significant when a parent presented with concordant cancer. The population attributable fraction of familial upper aerodigestive tract cancer was 0.43%. Risk for subsequent cancers in men and women after upper aerodigestive tract cancer were increased in smoking, alcohol and other life-style related sites and in skin cancer and non-Hodgkin's lymphoma.


External organisations
  • Karolinska Institutet
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology


  • Adolescent, Adult, Aged, Child, Child, Preschool, Cluster Analysis, Databases, Factual, Female, Follow-Up Studies, Head and Neck Neoplasms/epidemiology, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Neoplasms, Second Primary/epidemiology, Neoplastic Syndromes, Hereditary/epidemiology, Registries, Risk Factors, Sex Factors, Sweden/epidemiology
Original languageEnglish
Pages (from-to)232-9
Number of pages8
JournalOral Oncology
Issue number3
Publication statusPublished - 2003 Apr
Publication categoryResearch
Externally publishedYes