Fanconi's anaemia associated with haemophilia A

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Abstract

Fanconi's anaemia and haemophilia A are born inherited diseases creating haemostatic defects. The association of these two rare diseases in one patient is described. The patient's haemophilia was studied with a newly developed immunological technique determining the plasma antigen associated with Factor VIII activity, and was found to be a genetic variant of moderately severe haemophilia A. It was not possible to demonstrate a common bone marrow defect or a common immunological or genetical background of the two diseases. The double haemostatic defect created, i.e. Factor VIII deficiency and thrombocytopenia, resulted in only a slight increase in bleeding tendency. A favourable result was obtained with corticosteroid and androgenic treatment.

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Keywords

  • Abnormalities, Multiple, Anemia, Aplastic, Child, Factor VIII, Fanconi Anemia, Hemophilia A, Humans, Male, Thrombocytopenia, Case Reports, Journal Article
Original languageEnglish
Pages (from-to)364-8
Number of pages5
JournalClinical Genetics
Volume16
Issue number5
Publication statusPublished - 1979 Nov
Publication categoryResearch
Peer-reviewedYes