Faster progression to AIDS and AIDS-related death among seroincident individuals infected with recombinant HIV-1 A3/CRF02_AG compared to sub subtype A3.
Research output: Contribution to journal › Article
HIV-1 is divided into different subtypes and circulating recombinant forms (CRFs) but the impact of HIV-1 subtype/CRF on disease progression is not fully understood. We determined the HIV-1 subtype/CRF of 152 seroincident individuals from Guinea-Bissau, based on the C2-V3 region of env. Rate of disease progression was measured as time from estimated seroconversion to AIDS and AIDS-related death. Hazard ratios (HRs) were calculated using a Cox proportional hazard model, adjusting for gender and age at seroconversion. The major subtypes/CRFs identified were CRF02_AG (53%), A3 (29%) and A3/02 (a recombinant of A3 and CRF02_AG) (13%). Infection with A3/02 was associated with a close to 3-fold increased risk of AIDS and AIDS-related death compared to A3 (HR=2.6 [P=0.011] and 2.9 [P=0.032], respectively). The median estimated time from seroconversion to AIDS and AIDS-related death was 5.0 and 8.0 years for A3/02, 6.2 and 9.0 years for CRF02_AG and 7.2 and 11.3 years for A3. Our results show that there are significant differences in disease progression between HIV-1 A-like subtypes/CRFs. Individuals infected with the A3/02 recombinant have among the fastest progression rates to AIDS reported to date. Determining the HIV-1 subtype of infected individuals could be of importance in the management of HIV-1 infections.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Journal of Infectious Diseases|
|Publication status||Published - 2014|
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Infectious Diseases Research Unit (013242010), Virology (013017520), Division of Infection Medicine (SUS) (013008000), Oncology, MV (013035000), Department of Statistics (012014000), Division of Medical Microbiology (013250400), Clinical Virology, Malmö (013017580), Division of Hematology and Transfusion Medicine (013041100)
Related research output
HIV disease progression - Impact of HIV-1 intersubtype recombination and association with HIV-2 evolutionPalm, A., 2015, Department of Experimental Medical Science, Lund Univeristy. 87 p.
Research output: Thesis › Doctoral Thesis (compilation)