Feber og hudblødninger hos børn--er det meningokoksygdom?

Research output: Contribution to journalArticle

Standard

Feber og hudblødninger hos børn--er det meningokoksygdom? / Nielsen, Hans Erik; Andersen, Erik Arthur; Andersen, Jesper; Böttiger, Blenda; Christiansen, Karsten Maidahl; Daugbjerg, Peder Stjernholm; Larsen, Severin Olesen; Lind, Inga; Nir, Marta; Olofsson, Kern.

In: Ugeskrift for Laeger, Vol. 164, No. 20, 13.05.2002, p. 2617-2623.

Research output: Contribution to journalArticle

Harvard

Nielsen, HE, Andersen, EA, Andersen, J, Böttiger, B, Christiansen, KM, Daugbjerg, PS, Larsen, SO, Lind, I, Nir, M & Olofsson, K 2002, 'Feber og hudblødninger hos børn--er det meningokoksygdom?', Ugeskrift for Laeger, vol. 164, no. 20, pp. 2617-2623. <http://ugeskriftet.dk/videnskab/feber-og-hudbloedninger-hos-boern-er-det-meningokoksygdom>

APA

Nielsen, H. E., Andersen, E. A., Andersen, J., Böttiger, B., Christiansen, K. M., Daugbjerg, P. S., Larsen, S. O., Lind, I., Nir, M., & Olofsson, K. (2002). Feber og hudblødninger hos børn--er det meningokoksygdom? Ugeskrift for Laeger, 164(20), 2617-2623. http://ugeskriftet.dk/videnskab/feber-og-hudbloedninger-hos-boern-er-det-meningokoksygdom

CBE

Nielsen HE, Andersen EA, Andersen J, Böttiger B, Christiansen KM, Daugbjerg PS, Larsen SO, Lind I, Nir M, Olofsson K. 2002. Feber og hudblødninger hos børn--er det meningokoksygdom?. Ugeskrift for Laeger. 164(20):2617-2623.

MLA

Nielsen, Hans Erik et al. "Feber og hudblødninger hos børn--er det meningokoksygdom?". Ugeskrift for Laeger. 2002, 164(20). 2617-2623.

Vancouver

Nielsen HE, Andersen EA, Andersen J, Böttiger B, Christiansen KM, Daugbjerg PS et al. Feber og hudblødninger hos børn--er det meningokoksygdom? Ugeskrift for Laeger. 2002 May 13;164(20):2617-2623.

Author

Nielsen, Hans Erik ; Andersen, Erik Arthur ; Andersen, Jesper ; Böttiger, Blenda ; Christiansen, Karsten Maidahl ; Daugbjerg, Peder Stjernholm ; Larsen, Severin Olesen ; Lind, Inga ; Nir, Marta ; Olofsson, Kern. / Feber og hudblødninger hos børn--er det meningokoksygdom?. In: Ugeskrift for Laeger. 2002 ; Vol. 164, No. 20. pp. 2617-2623.

RIS

TY - JOUR

T1 - Feber og hudblødninger hos børn--er det meningokoksygdom?

AU - Nielsen, Hans Erik

AU - Andersen, Erik Arthur

AU - Andersen, Jesper

AU - Böttiger, Blenda

AU - Christiansen, Karsten Maidahl

AU - Daugbjerg, Peder Stjernholm

AU - Larsen, Severin Olesen

AU - Lind, Inga

AU - Nir, Marta

AU - Olofsson, Kern

PY - 2002/5/13

Y1 - 2002/5/13

N2 - INTRODUCTION: Our main aims were to establish criteria for early distinction between meningococcal disease and other conditions with similar clinical features, and to identify other causes of haemorrhagic rashes accompanied by fever.MATERIALS AND METHODS: This prospective study comprised 264 infants and children hospitalised with fever and skin haemorrhages.RESULTS: We identified an aetiological agent in 28%: 15% had meningococcal disease, 2% another invasive bacterial infection, 7% enterovirus infection, and 4% adenovirus infection. Five clinical variables discriminated meningococcal disease from other conditions on admission: skin haemorrhages of (1) characteristic appearance; (2) universal distribution and (3) a maximum diameter of > 2 mm; (4) poor general condition; and (5) nuchal rigidity.DISCUSSION: If any two or more of these clinical variables were present, the probability of identifying a patient with meningococcal disease was 97% and the false-positive rate was only 12%. This diagnostic algorithm did not identify children in whom septicaemia was caused by other bacterial species.

AB - INTRODUCTION: Our main aims were to establish criteria for early distinction between meningococcal disease and other conditions with similar clinical features, and to identify other causes of haemorrhagic rashes accompanied by fever.MATERIALS AND METHODS: This prospective study comprised 264 infants and children hospitalised with fever and skin haemorrhages.RESULTS: We identified an aetiological agent in 28%: 15% had meningococcal disease, 2% another invasive bacterial infection, 7% enterovirus infection, and 4% adenovirus infection. Five clinical variables discriminated meningococcal disease from other conditions on admission: skin haemorrhages of (1) characteristic appearance; (2) universal distribution and (3) a maximum diameter of > 2 mm; (4) poor general condition; and (5) nuchal rigidity.DISCUSSION: If any two or more of these clinical variables were present, the probability of identifying a patient with meningococcal disease was 97% and the false-positive rate was only 12%. This diagnostic algorithm did not identify children in whom septicaemia was caused by other bacterial species.

KW - Child

KW - Child, Preschool

KW - Diagnosis, Differential

KW - Fever/diagnosis

KW - Hemorrhage/diagnosis

KW - Humans

KW - Infant

KW - Meningitis, Bacterial/diagnosis

KW - Meningitis, Viral/diagnosis

KW - Meningococcal Infections/diagnosis

KW - Microbiological Techniques

KW - Prospective Studies

KW - Skin/pathology

KW - Skin Diseases, Bacterial/diagnosis

KW - Skin Diseases, Viral/diagnosis

M3 - Artikel i vetenskaplig tidskrift

C2 - 12043405

VL - 164

SP - 2617

EP - 2623

JO - Ugeskrift for Læger

JF - Ugeskrift for Læger

SN - 0041-5782

IS - 20

ER -