Fiber intake modulates the association of alcohol intake with breast cancer

Research output: Contribution to journalArticle


title = "Fiber intake modulates the association of alcohol intake with breast cancer",
abstract = "Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35–70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (<18.5 g/day), the risk of BC per 10 g/day of alcohol intake was 1.06 (1.03–1.08) while among subjects with high intake of fiber (>24.2 g/day) the risk of BC was 1.02 (0.99–1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber-rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (<18.5 g/day) had the highest risk for BC. Specific benefits were associated with fibers from vegetable, warranting further investigations into specific fiber sources and their mechanistic interactions with alcohol-induced BC risk.",
keywords = "alcohol, breast cancer, epidemiology, nutrition",
author = "Isabelle Romieu and Pietro Ferrari and Veronique Chaj{\`e}s and {de Batlle}, Jordi and Carine Biessy and Chiara Scoccianti and Laure Dossus and {Christine Boutron}, Marie and Nadia Bastide and Kim Overvad and Anja Olsen and Anne Tj{\o}nneland and Rudolf Kaaks and Heiner Boeing and Antonia Trichopoulou and Pagona Lagiou and Dimitrios Trichopoulos and Domenico Palli and Sabina Sieri and Rosario Tumino and Paolo Vineis and Salvatore Panico and Bueno-de-Mesquita, {H. Bas} and Gils, {Carla H.} and Peeters, {Petra H.} and Eiliv Lund and Guri Skeie and Elisabete Weiderpass and {Ram{\'o}n Quir{\'o}s}, J. and Chirlaque, {Mar{\'i}a Dolores} and Eva Ardanaz and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Duell, {Eric J.} and {Amiano Etxezarreta}, Pilar and Signe Borgquist and G{\"o}ran Hallmans and Ingegerd Johansson and {Maria Nilsson}, Lena and Khaw, {Kay Tee} and Nick Wareham and Key, {Timothy J.} and Travis, {Ruth C.} and Neil Murphy and Wark, {Petra A.} and Elio Riboli",
year = "2017",
month = jan,
day = "15",
doi = "10.1002/ijc.30415",
language = "English",
volume = "140",
pages = "316--321",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "John Wiley and Sons",
number = "2",