Fiber intake modulates the association of alcohol intake with breast cancer

Research output: Contribution to journalArticle

Standard

Fiber intake modulates the association of alcohol intake with breast cancer. / Romieu, Isabelle; Ferrari, Pietro; Chajès, Veronique; de Batlle, Jordi; Biessy, Carine; Scoccianti, Chiara; Dossus, Laure; Christine Boutron, Marie; Bastide, Nadia; Overvad, Kim; Olsen, Anja; Tjønneland, Anne; Kaaks, Rudolf; Boeing, Heiner; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Vineis, Paolo; Panico, Salvatore; Bueno-de-Mesquita, H. Bas; Gils, Carla H.; Peeters, Petra H.; Lund, Eiliv; Skeie, Guri; Weiderpass, Elisabete; Ramón Quirós, J.; Chirlaque, María Dolores; Ardanaz, Eva; Sánchez, María José; Duell, Eric J.; Amiano Etxezarreta, Pilar; Borgquist, Signe; Hallmans, Göran; Johansson, Ingegerd; Maria Nilsson, Lena; Khaw, Kay Tee; Wareham, Nick; Key, Timothy J.; Travis, Ruth C.; Murphy, Neil; Wark, Petra A.; Riboli, Elio.

In: International Journal of Cancer, Vol. 140, No. 2, 15.01.2017, p. 316-321.

Research output: Contribution to journalArticle

Harvard

Romieu, I, Ferrari, P, Chajès, V, de Batlle, J, Biessy, C, Scoccianti, C, Dossus, L, Christine Boutron, M, Bastide, N, Overvad, K, Olsen, A, Tjønneland, A, Kaaks, R, Boeing, H, Trichopoulou, A, Lagiou, P, Trichopoulos, D, Palli, D, Sieri, S, Tumino, R, Vineis, P, Panico, S, Bueno-de-Mesquita, HB, Gils, CH, Peeters, PH, Lund, E, Skeie, G, Weiderpass, E, Ramón Quirós, J, Chirlaque, MD, Ardanaz, E, Sánchez, MJ, Duell, EJ, Amiano Etxezarreta, P, Borgquist, S, Hallmans, G, Johansson, I, Maria Nilsson, L, Khaw, KT, Wareham, N, Key, TJ, Travis, RC, Murphy, N, Wark, PA & Riboli, E 2017, 'Fiber intake modulates the association of alcohol intake with breast cancer', International Journal of Cancer, vol. 140, no. 2, pp. 316-321. https://doi.org/10.1002/ijc.30415

APA

Romieu, I., Ferrari, P., Chajès, V., de Batlle, J., Biessy, C., Scoccianti, C., Dossus, L., Christine Boutron, M., Bastide, N., Overvad, K., Olsen, A., Tjønneland, A., Kaaks, R., Boeing, H., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Sieri, S., ... Riboli, E. (2017). Fiber intake modulates the association of alcohol intake with breast cancer. International Journal of Cancer, 140(2), 316-321. https://doi.org/10.1002/ijc.30415

CBE

Romieu I, Ferrari P, Chajès V, de Batlle J, Biessy C, Scoccianti C, Dossus L, Christine Boutron M, Bastide N, Overvad K, Olsen A, Tjønneland A, Kaaks R, Boeing H, Trichopoulou A, Lagiou P, Trichopoulos D, Palli D, Sieri S, Tumino R, Vineis P, Panico S, Bueno-de-Mesquita HB, Gils CH, Peeters PH, Lund E, Skeie G, Weiderpass E, Ramón Quirós J, Chirlaque MD, Ardanaz E, Sánchez MJ, Duell EJ, Amiano Etxezarreta P, Borgquist S, Hallmans G, Johansson I, Maria Nilsson L, Khaw KT, Wareham N, Key TJ, Travis RC, Murphy N, Wark PA, Riboli E. 2017. Fiber intake modulates the association of alcohol intake with breast cancer. International Journal of Cancer. 140(2):316-321. https://doi.org/10.1002/ijc.30415

MLA

Vancouver

Romieu I, Ferrari P, Chajès V, de Batlle J, Biessy C, Scoccianti C et al. Fiber intake modulates the association of alcohol intake with breast cancer. International Journal of Cancer. 2017 Jan 15;140(2):316-321. https://doi.org/10.1002/ijc.30415

Author

Romieu, Isabelle ; Ferrari, Pietro ; Chajès, Veronique ; de Batlle, Jordi ; Biessy, Carine ; Scoccianti, Chiara ; Dossus, Laure ; Christine Boutron, Marie ; Bastide, Nadia ; Overvad, Kim ; Olsen, Anja ; Tjønneland, Anne ; Kaaks, Rudolf ; Boeing, Heiner ; Trichopoulou, Antonia ; Lagiou, Pagona ; Trichopoulos, Dimitrios ; Palli, Domenico ; Sieri, Sabina ; Tumino, Rosario ; Vineis, Paolo ; Panico, Salvatore ; Bueno-de-Mesquita, H. Bas ; Gils, Carla H. ; Peeters, Petra H. ; Lund, Eiliv ; Skeie, Guri ; Weiderpass, Elisabete ; Ramón Quirós, J. ; Chirlaque, María Dolores ; Ardanaz, Eva ; Sánchez, María José ; Duell, Eric J. ; Amiano Etxezarreta, Pilar ; Borgquist, Signe ; Hallmans, Göran ; Johansson, Ingegerd ; Maria Nilsson, Lena ; Khaw, Kay Tee ; Wareham, Nick ; Key, Timothy J. ; Travis, Ruth C. ; Murphy, Neil ; Wark, Petra A. ; Riboli, Elio. / Fiber intake modulates the association of alcohol intake with breast cancer. In: International Journal of Cancer. 2017 ; Vol. 140, No. 2. pp. 316-321.

RIS

TY - JOUR

T1 - Fiber intake modulates the association of alcohol intake with breast cancer

AU - Romieu, Isabelle

AU - Ferrari, Pietro

AU - Chajès, Veronique

AU - de Batlle, Jordi

AU - Biessy, Carine

AU - Scoccianti, Chiara

AU - Dossus, Laure

AU - Christine Boutron, Marie

AU - Bastide, Nadia

AU - Overvad, Kim

AU - Olsen, Anja

AU - Tjønneland, Anne

AU - Kaaks, Rudolf

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Trichopoulos, Dimitrios

AU - Palli, Domenico

AU - Sieri, Sabina

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Panico, Salvatore

AU - Bueno-de-Mesquita, H. Bas

AU - Gils, Carla H.

AU - Peeters, Petra H.

AU - Lund, Eiliv

AU - Skeie, Guri

AU - Weiderpass, Elisabete

AU - Ramón Quirós, J.

AU - Chirlaque, María Dolores

AU - Ardanaz, Eva

AU - Sánchez, María José

AU - Duell, Eric J.

AU - Amiano Etxezarreta, Pilar

AU - Borgquist, Signe

AU - Hallmans, Göran

AU - Johansson, Ingegerd

AU - Maria Nilsson, Lena

AU - Khaw, Kay Tee

AU - Wareham, Nick

AU - Key, Timothy J.

AU - Travis, Ruth C.

AU - Murphy, Neil

AU - Wark, Petra A.

AU - Riboli, Elio

PY - 2017/1/15

Y1 - 2017/1/15

N2 - Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35–70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (<18.5 g/day), the risk of BC per 10 g/day of alcohol intake was 1.06 (1.03–1.08) while among subjects with high intake of fiber (>24.2 g/day) the risk of BC was 1.02 (0.99–1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber-rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (<18.5 g/day) had the highest risk for BC. Specific benefits were associated with fibers from vegetable, warranting further investigations into specific fiber sources and their mechanistic interactions with alcohol-induced BC risk.

AB - Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35–70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (<18.5 g/day), the risk of BC per 10 g/day of alcohol intake was 1.06 (1.03–1.08) while among subjects with high intake of fiber (>24.2 g/day) the risk of BC was 1.02 (0.99–1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber-rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (<18.5 g/day) had the highest risk for BC. Specific benefits were associated with fibers from vegetable, warranting further investigations into specific fiber sources and their mechanistic interactions with alcohol-induced BC risk.

KW - alcohol

KW - breast cancer

KW - epidemiology

KW - nutrition

UR - http://www.scopus.com/inward/record.url?scp=84995932379&partnerID=8YFLogxK

U2 - 10.1002/ijc.30415

DO - 10.1002/ijc.30415

M3 - Article

C2 - 27599758

AN - SCOPUS:84995932379

VL - 140

SP - 316

EP - 321

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 2

ER -