Fibroblast growth factor stimulates bone formation bone induction studied in rats

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Fibroblast growth factor stimulates bone formation bone induction studied in rats. / Aspenberg, Per; Lohmander, Stefan.

In: Acta Orthopaedica, Vol. 60, No. 4, 1989, p. 473-476.

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TY - JOUR

T1 - Fibroblast growth factor stimulates bone formation bone induction studied in rats

AU - Aspenberg, Per

AU - Lohmander, Stefan

PY - 1989

Y1 - 1989

N2 - Implantation of demineralized bone matrix in rodents elicits a series of cellular events leading to the formation of new bone inside and adjacent to the implant. This process is believed to be initiated by an inductive protein present in bone matrix. It has been suggested that local growth factors may further regulate the process once it has been initiated. This investigation was designed to study the effect of adding a growth factor to the inductive implant. Pairs of demineralized rat femoral diaphyses were implanted intramuscularly in rats. the marrow canal of one implant in each pair was filled with a carboxymethyl cellulose gel containing 75 ng of recombinant human basic fibroblast growth factor (FGF). the other implant in each pair served as a control. It was either filled with the gel without FGF or left untreated. Bone formation was induced by all the implants after 3 weeks. the amount of mineralized tissue in the FGF-treated implants was 25 percent greater than in untreated controls. the carboxymethyl cellulose gel alone did not affect the bone yield.

AB - Implantation of demineralized bone matrix in rodents elicits a series of cellular events leading to the formation of new bone inside and adjacent to the implant. This process is believed to be initiated by an inductive protein present in bone matrix. It has been suggested that local growth factors may further regulate the process once it has been initiated. This investigation was designed to study the effect of adding a growth factor to the inductive implant. Pairs of demineralized rat femoral diaphyses were implanted intramuscularly in rats. the marrow canal of one implant in each pair was filled with a carboxymethyl cellulose gel containing 75 ng of recombinant human basic fibroblast growth factor (FGF). the other implant in each pair served as a control. It was either filled with the gel without FGF or left untreated. Bone formation was induced by all the implants after 3 weeks. the amount of mineralized tissue in the FGF-treated implants was 25 percent greater than in untreated controls. the carboxymethyl cellulose gel alone did not affect the bone yield.

KW - animals

KW - bone matrix

UR - http://www.scopus.com/inward/record.url?scp=0024474028&partnerID=8YFLogxK

U2 - 10.3109/17453678909149323

DO - 10.3109/17453678909149323

M3 - Article

VL - 60

SP - 473

EP - 476

JO - Acta Orthopaedica

T2 - Acta Orthopaedica

JF - Acta Orthopaedica

SN - 1745-3682

IS - 4

ER -