Filling the Gap – Improving Awareness and Practice in Hyponatraemia and the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) in the Older Patient: A European Consensus View

Research output: Contribution to journalArticle


Introduction: Causes of hyponatraemia in older patients are multivariate and in the case of SIADH may often be drug induced. Diagnostic and treatment algorithms are unclear for this important age group. Methods: The author group identified 6 broad themes for consensus and formulated 42 separate consensus statements within these 6 themes. Statements were then circulated to geriatricians, general practitioners and other doctors to test agreement at the European level. Results: 64 responses were evaluated from around Europe. Agreement was achieved in 86% of the statements following amendment and redistribution of 6 of the statements. The survey and its feedback prompted the development of 13 recommendations related to the diagnosis and treatment of hyponatraemia including SIADH. Conclusion: The series of 13 recommendations developed here is intended to increase clarity for clinicians managing older patients with hyponatraemia and SIADH. Surprisingly, despite the lack of clear guidelines or recommendations for this age group consensus levels for the author-based statements were high among the respondents.


  • M. Wehling
  • C. Ashton
  • E. Ekpo
  • S. Gwynn
  • M. Laville
  • K. Olsson
  • M. Spring
External organisations
  • Heidelberg University
  • South Warwickshire NHS Foundation Trust
  • Lewisham and Greenwich NHS Trust
  • SG Market Access Ltd
  • Centre Hospitalier Lyon Sud
  • Kingston NHS Foundation Trust
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology


  • algorithms, geriatric pharmacotherapy, hyponatraemia, older patients, SIADH
Original languageEnglish
Pages (from-to)5-12
JournalDrug Research
Issue number1
Early online date2016 Aug 9
Publication statusPublished - 2017
Publication categoryResearch