First trimester enterovirus IgM and beta cell autoantibodies in mothers to children affected by type 1 diabetes autoimmunity before 7 years of age

Research output: Contribution to journalArticle

Abstract

Background: Autoimmune (type 1) diabetes (T1D) is a frequent chronic disease in children and adolescents globally. Gestational enterovirus (EV) infections have been associated with an increased risk for T1D in the offspring. We test the hypothesis that EV infections during the first trimester were associated with beta cell autoantibodies in mothers of children who developed islet autoantibodies before 7 years of age. Materials and methods: Local registries were used to identify mothers to children born 2000–2007 who developed either beta cell autoantibodies or T1D during follow up. Serum samples from the first trimester were located in the Biobank. A total of 448 index mothers were identified and compared to 891 matched control mothers. EV-IgM was determined in a capture enzyme immunoassay. Beta cell autoantibodies were analyzed in standard radio binding assays. Results: The frequency of EV-IgM in index mothers was 20% (89/448), which did not differ from the control mothers 20% (175/891) (p = 0.922). Index mothers had multiple beta cell autoantibodies more often than control mothers (p = 0.037). Beta cell autoantibodies were increased during the November–April winter months in index compared to control mothers (p = 0.022). The observed difference was possibly explained by the months of February-April (p = 0.014). Concomitant EV-IgM and beta cell autoantibodies tended to be more common among index compared to control mothers (p = 0.039). Conclusion: EV-IgM during the first trimester may be associated with beta cell autoantibodies in mothers to children who developed either beta cell autoantibodies or T1D before 7 years of age.

Details

Authors
Organisations
External organisations
  • Skåne University Hospital
  • University of South Florida
  • University of Tampere
  • Pirkanmaa Hospital District
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Immunology in the medical area
  • Endocrinology and Diabetes

Keywords

  • Autoantibodies, Beta cell autoimmunity, Biobank, Capture enzyme Immunoassay, Childhood diabetes, Enterovirus, Epidemiology, EV IgM analysis, GAD65, Gestational infections, IA-2, Neutralization assay, Type 1 diabetes, Virus infections, ZnT8
Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalJournal of Reproductive Immunology
Volume127
Publication statusPublished - 2018 Jun 1
Publication categoryResearch
Peer-reviewedYes