First-order nociceptive synapses in rat dorsal horn are blocked by an amino acid antagonist

Research output: Contribution to journalArticle

Abstract

An antagonist to amino acid evoked excitation, γ-d-glutamylglycine (γ-DGG) inhibits, dose-dependently, nociceptive C-fibre evoked field potentials and neuronal discharges in single nociceptive neurons in rat spinal cord. It is concluded that amino acids are possible transmitter substance(s) in nociceptive afferent C-fibres. These results might be useful for development of centrally acting analgesic drugs.

Details

Authors
Organisations
External organisations
  • Medical Board of the Armed Forces
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • dorsal horn, glutamate, nociceptive primary afferent fibre, pain
Original languageEnglish
Pages (from-to)394-398
Number of pages5
JournalBrain Research
Volume379
Issue number2
Publication statusPublished - 1986 Aug 6
Publication categoryResearch
Peer-reviewedYes