First-trimester diagnosis on chorionic villi obtained by direct vision technique

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Abstract

An improved technique for direct vision chorionic biopsy that gives a clear view of the amniotic sac was developed. With this technique, used in 48 women prior to vacuum aspiration and in six cases for diagnosis (karyotyping or enzyme analysis), it was possible to obtain chorionic villi free from contamination by maternal tissue. It was also possible to pick out villi (rich in blood vessels and with abundant buds on their surface) found to be most capable of growing in vitro. In the diagnostic cases, the pregnancies have continued uneventfully since the sampling; one pregnancy is now in the 32nd week.

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  • Medical Genetics
Original languageEnglish
Pages (from-to)373-376
JournalHuman Genetics
Volume65
Issue number4
Publication statusPublished - 1984
Publication categoryResearch
Peer-reviewedYes