Flow cytometric DNA ploidy and number of cell populations in the primary breast cancer and their correlation to the prognosis.

Research output: Contribution to journalArticle

Abstract

In a prospective study on 516 breast cancer patients flow cytometry DNA ploidy and number of cell populations (defined as number of DNA stem lines) detected in the primary tumor were evaluated for prognostic purposes. the median follow-up time was about 5 years. in the 241 node negative cases, those patients with three or more cell populations had the worst prognosis, with a distant recurrence-free survival rate of about 60% at five years compared to 90% in cases with only one cell population detected in the primary tumor. the number of tumor involved axillary lymph nodes was the outstanding prognostic indicator which was confirmed in 275 node positive patients; DNA ploidy and number of cell populations did not give any significant prognostic information in this group of patients.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • cell populations, DNA ploidy, flow cytometry, stage, prognosis, Breast cancer
Original languageEnglish
Pages (from-to)913-918
JournalActa Oncologica
Volume28
Issue number6
Publication statusPublished - 1989
Publication categoryResearch
Peer-reviewedYes