Flow sensing in the cardiovascular system

Research output: Contribution to journalArticle

Abstract

Background: This contribution deals with chemical processes at the biological membranes of endothelial cells in blood vessels. A basic observation is that the intensity of blood flow navigates the vascular width through a negative feedback circle. When the blood flow increases, the vessels become wider; when it decreases the vascular smooth muscle cells contract. The anionic polyelectrolyte heparan sulfate proteoglycan (HS-PG) reacts to the shear stress generated by the flowing blood. In the present investigation, this naturally occurring biosensor is characterized in more detail, which is crucially involved in the regulation of peripheral blood flow and organ perfusion. A dysfunction of this sensor can lead to organ insufficiency, hypertension and arteriosclerosis.

Details

Authors
  • G. Siegel
  • G. Meyer-Rath
  • E. Ermilov
  • M. Rodriguez
  • M. Malmsten
  • P. Claesson
  • R. Saunders
  • R. Hetzer
  • Björn Lindman
Organisations
External organisations
  • University of Coimbra
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Physiology

Keywords

  • Endothelial flow sensor syndecan (HS/CS-PG)
Original languageEnglish
Pages (from-to)318-327
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume480
Publication statusPublished - 2015
Publication categoryResearch
Peer-reviewedYes