Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)

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title = "Fluid intake and the risk of urothelial cell carcinomas in the European Prospective Investigation into Cancer and Nutrition (EPIC)",
abstract = "Results from previous studies investigating the association between fluid intake and urothelial cell carcinomas (UCC) are inconsistent. We evaluated this association among 233,236 subjects in the European Prospective Investigation into Cancer and Nutrition (EPIC), who had adequate baseline information on water and total fluid intake. During a mean follow-up of 9.3 years, 513 first primary UCC occurred. At recruitment, habitual fluid intake was assessed by a food frequency questionnaire. Multivariable hazard ratios were estimated using Cox regression stratified by age, sex and center and adjusted for energy intake, smoking status, duration of smoking and lifetime intensity of smoking. When using the lowest tertile of intake as reference, total fluid intake was not associated with risk of all UCC (HR 1.12; 95% CI 0.86-1.45, p-trend = 0.42) or with risk of prognostically high-risk UCC (HR 1.28; 95% CI 0.85-1.93, p-trend = 0.27) or prognostically low-risk UCC (HR 0.93; 95% CI 0.65-1.33, p-trend = 0.74). No associations were observed between risk of UCC and intake of water, coffee, tea and herbal tea and milk and other dairy beverages. For prognostically low-risk UCC suggestions of an inverse association with alcoholic beverages and of a positive association with soft drinks were seen. Increased risks were found for all UCC and prognostically low-risk UCC with higher intake of fruit and vegetable juices. In conclusion, total usual fluid intake is not associated with UCC risk in EPIC. The relationships observed for some fluids may be due to chance, but further investigation of the role of all types of fluid is warranted.",
keywords = "urothelial cell carcinomas, bladder cancer, fluid, EPIC",
author = "Ros, {Martine M.} and Bueno-de-Mesquita, {H. B. Bas} and Buchner, {Frederike L.} and Aben, {Katja K. H.} and Ellen Kampman and Lars Egevad and Kim Overvad and Anne Tjonneland and Nina Roswall and Francoise Clavel-Chapelon and Rudolf Kaaks and Jenny Chang-Claude and Heiner Boeing and Steffen Weikert and Antonia Trichopoulou and Philippos Orfanos and Georgia Stasinopulou and Calogero Saieva and Vittorio Krogh and Paolo Vineis and Rosario Tumino and Amalia Mattiello and Peeters, {Petra H. M.} and {van Duijnhoven}, {Franzel J. B.} and Eiliv Lund and Gram, {Inger T.} and Chirlaque, {Maria D.} and Aurelio Barricarte and Laudina Rodriguez and Esther Molina and Carlos Gonzalez and Miren Dorronsoro and Jonas Manjer and Roy Ehrnstr{\"o}m and Borje Ljungberg and Allen, {Naomi E.} and Roddam, {Andrew W.} and Kay-Tee Khaw and Nick Wareham and Paolo Boffetta and Nadia Slimani and Michaud, {Dominique S.} and Kiemeney, {Lambertus A. L. M.} and Elio Riboli",
year = "2011",
doi = "10.1002/ijc.25592",
language = "English",
volume = "128",
pages = "2695--2708",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "John Wiley and Sons",
number = "11",