Fluorescence enhancement of single DNA molecules confined in Si/SiO2 nanochannels

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Abstract

We demonstrate that the detected emission intensity from YOYO-labeled DNA molecules confined in 180 nm deep Si/SiO2 nano-funnels changes significantly and not monotonically with the width of the funnel. This effect may be of importance for quantitative fluorescence microscopy and for experiments with a tight photon budget.

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  • Condensed Matter Physics
Original languageEnglish
Pages (from-to)2049-2051
JournalLab on a Chip
Volume10
Issue number16
Publication statusPublished - 2010
Publication categoryResearch
Peer-reviewedYes