Formation of solid organic nanoparticles from a volatile catanionic microemulsion

Research output: Contribution to journalArticle

Standard

Formation of solid organic nanoparticles from a volatile catanionic microemulsion. / Margulis-Goshen, Katrin; Silva, Bruno; Marques, Eduardo F.; Magdassi, Shlomo.

In: Soft Matter, Vol. 7, No. 19, 2011, p. 9359-9365.

Research output: Contribution to journalArticle

Harvard

Margulis-Goshen, K, Silva, B, Marques, EF & Magdassi, S 2011, 'Formation of solid organic nanoparticles from a volatile catanionic microemulsion', Soft Matter, vol. 7, no. 19, pp. 9359-9365. https://doi.org/10.1039/c1sm05637a

APA

Margulis-Goshen, K., Silva, B., Marques, E. F., & Magdassi, S. (2011). Formation of solid organic nanoparticles from a volatile catanionic microemulsion. Soft Matter, 7(19), 9359-9365. https://doi.org/10.1039/c1sm05637a

CBE

MLA

Vancouver

Author

Margulis-Goshen, Katrin ; Silva, Bruno ; Marques, Eduardo F. ; Magdassi, Shlomo. / Formation of solid organic nanoparticles from a volatile catanionic microemulsion. In: Soft Matter. 2011 ; Vol. 7, No. 19. pp. 9359-9365.

RIS

TY - JOUR

T1 - Formation of solid organic nanoparticles from a volatile catanionic microemulsion

AU - Margulis-Goshen, Katrin

AU - Silva, Bruno

AU - Marques, Eduardo F.

AU - Magdassi, Shlomo

PY - 2011

Y1 - 2011

N2 - A novel volatile microemulsion formed by the catanionic surfactant hexadecyltrimethylammonium octylsulfonate (TA(16)So(8)), heptane and water has been explored as a template for producing nanoparticles of hydrophobic organic materials. Butylated hydroxytoluene (BHT) was employed as the model hydrophobic substance. First, the oil-in-water microemulsion was formed, containing TA16So8 as the single emulsifier and BHT dispersed in the volatile microphase. Microstructure characterization by self-diffusion NMR revealed that BHT was indeed incorporated into the oil droplets and that the mean diameter of the main droplet population was 30 nm, larger than in the BHT-free microemulsion. Next, a rapid solvent and water removal by freeze drying allowed converting the microemulsion droplets into nanoparticles in the form of a dry, fine powder. This powder was freely dispersible in water to yield a stable suspension of amorphous BHT particles with a mean size of 19 nm and zeta-potential of +37 mV. The solid nanoparticles in the aqueous dispersion were thus smaller than the initial microemulsion droplets. For comparison, a conventional o/w microemulsion composed of CTAB and sec-butanol was also tested as a template for BHT particle formation by the same process, and it was found that it yielded crystalline particles of micrometre size. On the basis of our results, we anticipate the catanionic microemulsion method to be an efficient one for producing size-controlled, water-dispersible nanoparticles of other hydrophobic organic materials.

AB - A novel volatile microemulsion formed by the catanionic surfactant hexadecyltrimethylammonium octylsulfonate (TA(16)So(8)), heptane and water has been explored as a template for producing nanoparticles of hydrophobic organic materials. Butylated hydroxytoluene (BHT) was employed as the model hydrophobic substance. First, the oil-in-water microemulsion was formed, containing TA16So8 as the single emulsifier and BHT dispersed in the volatile microphase. Microstructure characterization by self-diffusion NMR revealed that BHT was indeed incorporated into the oil droplets and that the mean diameter of the main droplet population was 30 nm, larger than in the BHT-free microemulsion. Next, a rapid solvent and water removal by freeze drying allowed converting the microemulsion droplets into nanoparticles in the form of a dry, fine powder. This powder was freely dispersible in water to yield a stable suspension of amorphous BHT particles with a mean size of 19 nm and zeta-potential of +37 mV. The solid nanoparticles in the aqueous dispersion were thus smaller than the initial microemulsion droplets. For comparison, a conventional o/w microemulsion composed of CTAB and sec-butanol was also tested as a template for BHT particle formation by the same process, and it was found that it yielded crystalline particles of micrometre size. On the basis of our results, we anticipate the catanionic microemulsion method to be an efficient one for producing size-controlled, water-dispersible nanoparticles of other hydrophobic organic materials.

U2 - 10.1039/c1sm05637a

DO - 10.1039/c1sm05637a

M3 - Article

VL - 7

SP - 9359

EP - 9365

JO - Soft Matter

JF - Soft Matter

SN - 1744-6848

IS - 19

ER -