Frequent miRNA-convergent fusion gene events in breast cancer

Research output: Contribution to journalArticle


title = "Frequent miRNA-convergent fusion gene events in breast cancer",
abstract = "Studies of fusion genes have mainly focused on the formation of fusions that result in the production of hybrid proteins or, alternatively, on promoter-switching events that put a gene under the control of aberrant signals. However, gene fusions may also disrupt the transcriptional control of genes that are encoded in introns downstream of the breakpoint. By ignoring structural constraints of the transcribed fusions, we highlight the importance of a largely unexplored function of fusion genes. Here, we show, using breast cancer as an example, that miRNA host genes are specifically enriched in fusion genes and that many different, low-frequency, 5 partners may deregulate the same miRNA irrespective of the coding potential of the fusion transcript. These results indicate that the concept of recurrence, defined by the rate of functionally important aberrations, needs to be revised to encompass convergent fusions that affect a miRNA independently of transcript structure and protein-coding potential.",
author = "Helena Persson and Rolf S{\o}kilde and Jari H{\"a}kkinen and Pirona, {Anna Chiara} and Johan Vallon-Christersson and Anders Kvist and Fredrik Mertens and {\AA}ke Borg and Felix Mitelman and Mattias H{\"o}glund and Carlos Rovira",
year = "2017",
month = "12",
day = "1",
doi = "10.1038/s41467-017-01176-1",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",