From the bone marrow to the thymus: the road map of early stages of T-cell development.

Research output: Contribution to journalReview article

Abstract

The thymus produces new T cells throughout life but has no self-renewing ability and requires replenishment and recruitment of progenitors derived from the bone marrow. Despite the progress in delineation of mature blood cell development several questions remain regarding T lymphopoiesis. Understanding the developmental stages from multipotent hematopoietic stem cells (HSCs) to the T-cell lineage-restricted progenitors has many potential clinical implications as it is important for understanding malignant transformation in T-cell cancer, accelerating T-cell regeneration after bone marrow transplantation and chemotherapy, and establishing new therapies to treat T-cell immune deficiencies. This review focuses on the steps leading from the HSCs in the bone marrow to the lineage committed T cells inside the thymus.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cell and Molecular Biology

Keywords

  • T-Lymphocytes: immunology, Thymus Gland: cytology, Thymus Gland: immunology, Bone Marrow: immunology, T-Lymphocytes: cytology
Original languageEnglish
Pages (from-to)487-530
JournalCritical Reviews in Immunology
Volume29
Issue number6
Publication statusPublished - 2009
Publication categoryResearch
Peer-reviewedYes