FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals.

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title = "FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals.",
abstract = "FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] {\%}, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] {\%}, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.",
author = "Qibin Qi and Kilpel{\"a}inen, {Tuomas O} and Downer, {Mary K} and Toshiko Tanaka and Smith, {Caren E} and Ivonne Sluijs and Emily Sonestedt and Chu, {Audrey Y} and Frida Renstr{\"o}m and Xiaochen Lin and Angquist, {Lars H} and Jinyan Huang and Zhonghua Liu and Yanping Li and {Asif Ali}, Muhammad and Min Xu and Ahluwalia, {Tarunveer Singh} and Boer, {Jolanda M A} and Peng Chen and Makoto Daimon and Johan Eriksson and Markus Perola and Yechiel Friedlander and Yu-Tang Gao and Heppe, {Denise H M} and Holloway, {John W} and Houston, {Denise K} and Stavroula Kanoni and Yu-Mi Kim and Laaksonen, {Maarit A} and Tiina J{\"a}{\"a}skel{\"a}inen and Lee, {Nanette R} and Terho Lehtim{\"a}ki and Lemaitre, {Rozenn N} and Wei Lu and Luben, {Robert N} and Ani Manichaikul and Satu M{\"a}nnist{\"o} and Pedro Marques-Vidal and Monda, {Keri L} and Ngwa, {Julius S} and Louis Perusse and {van Rooij}, {Frank J A} and Yong-Bing Xiang and Wanqing Wen and Wojczynski, {Mary K} and Jingwen Zhu and Borecki, {Ingrid B} and Claude Bouchard and Qiuyin Cai and Cyrus Cooper and Dedoussis, {George V} and Panos Deloukas and Luigi Ferrucci and Forouhi, {Nita G} and Torben Hansen and Lene Christiansen and Albert Hofman and Ingegerd Johansson and Torben J{\o}rgensen and Shigeru Karasawa and Kay-Tee Khaw and Mi-Kyung Kim and Kati Kristiansson and Huaixing Li and Xu Lin and Yongmei Liu and Lohman, {Kurt K} and Jirong Long and Vera Mikkil{\"a} and Dariush Mozaffarian and Kari North and Oluf Pedersen and Olli Raitakari and Harri Rissanen and Jaakko Tuomilehto and {van der Schouw}, {Yvonne T} and Uitterlinden, {Andr{\'e} G} and {Carola Zillikens}, M and Franco, {Oscar H} and {Shyong Tai}, E and {Ou Shu}, Xiao and Siscovick, {David S} and Ulla Toft and {Monique Verschuren}, {W M} and Peter Vollenweider and Wareham, {Nicholas J} and Witteman, {Jacqueline C M} and Wei Zheng and Ridker, {Paul M} and Kang, {Jae H} and Liming Liang and Jensen, {Majken K} and Curhan, {Gary C} and Pasquale, {Louis R} and Hunter, {David J} and Mohlke, {Karen L} and Matti Uusitupa and {Adrienne Cupples}, L and Tuomo Rankinen and Marju Orho-Melander and Tao Wang and Chasman, {Daniel I} and Paul Franks and S{\o}rensen, {Thorkild I A} and Hu, {Frank B} and Loos, {Ruth J F} and Nettleton, {Jennifer A} and Lu Qi",
year = "2014",
doi = "10.1093/hmg/ddu411",
language = "English",
volume = "23",
pages = "6961--6972",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "25",