FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals.

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FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals. / Qi, Qibin; Kilpeläinen, Tuomas O; Downer, Mary K; Tanaka, Toshiko; Smith, Caren E; Sluijs, Ivonne; Sonestedt, Emily; Chu, Audrey Y; Renström, Frida; Lin, Xiaochen; Angquist, Lars H; Huang, Jinyan; Liu, Zhonghua; Li, Yanping; Asif Ali, Muhammad; Xu, Min; Ahluwalia, Tarunveer Singh; Boer, Jolanda M A; Chen, Peng; Daimon, Makoto; Eriksson, Johan; Perola, Markus; Friedlander, Yechiel; Gao, Yu-Tang; Heppe, Denise H M; Holloway, John W; Houston, Denise K; Kanoni, Stavroula; Kim, Yu-Mi; Laaksonen, Maarit A; Jääskeläinen, Tiina; Lee, Nanette R; Lehtimäki, Terho; Lemaitre, Rozenn N; Lu, Wei; Luben, Robert N; Manichaikul, Ani; Männistö, Satu; Marques-Vidal, Pedro; Monda, Keri L; Ngwa, Julius S; Perusse, Louis; van Rooij, Frank J A; Xiang, Yong-Bing; Wen, Wanqing; Wojczynski, Mary K; Zhu, Jingwen; Borecki, Ingrid B; Bouchard, Claude; Cai, Qiuyin; Cooper, Cyrus; Dedoussis, George V; Deloukas, Panos; Ferrucci, Luigi; Forouhi, Nita G; Hansen, Torben; Christiansen, Lene; Hofman, Albert; Johansson, Ingegerd; Jørgensen, Torben; Karasawa, Shigeru; Khaw, Kay-Tee; Kim, Mi-Kyung; Kristiansson, Kati; Li, Huaixing; Lin, Xu; Liu, Yongmei; Lohman, Kurt K; Long, Jirong; Mikkilä, Vera; Mozaffarian, Dariush; North, Kari; Pedersen, Oluf; Raitakari, Olli; Rissanen, Harri; Tuomilehto, Jaakko; van der Schouw, Yvonne T; Uitterlinden, André G; Carola Zillikens, M; Franco, Oscar H; Shyong Tai, E; Ou Shu, Xiao; Siscovick, David S; Toft, Ulla; Monique Verschuren, W M; Vollenweider, Peter; Wareham, Nicholas J; Witteman, Jacqueline C M; Zheng, Wei; Ridker, Paul M; Kang, Jae H; Liang, Liming; Jensen, Majken K; Curhan, Gary C; Pasquale, Louis R; Hunter, David J; Mohlke, Karen L; Uusitupa, Matti; Adrienne Cupples, L; Rankinen, Tuomo; Orho-Melander, Marju; Wang, Tao; Chasman, Daniel I; Franks, Paul; Sørensen, Thorkild I A; Hu, Frank B; Loos, Ruth J F; Nettleton, Jennifer A; Qi, Lu.

In: Human Molecular Genetics, Vol. 23, No. 25, 2014, p. 6961-6972.

Research output: Contribution to journalArticle

Harvard

Qi, Q, Kilpeläinen, TO, Downer, MK, Tanaka, T, Smith, CE, Sluijs, I, Sonestedt, E, Chu, AY, Renström, F, Lin, X, Angquist, LH, Huang, J, Liu, Z, Li, Y, Asif Ali, M, Xu, M, Ahluwalia, TS, Boer, JMA, Chen, P, Daimon, M, Eriksson, J, Perola, M, Friedlander, Y, Gao, Y-T, Heppe, DHM, Holloway, JW, Houston, DK, Kanoni, S, Kim, Y-M, Laaksonen, MA, Jääskeläinen, T, Lee, NR, Lehtimäki, T, Lemaitre, RN, Lu, W, Luben, RN, Manichaikul, A, Männistö, S, Marques-Vidal, P, Monda, KL, Ngwa, JS, Perusse, L, van Rooij, FJA, Xiang, Y-B, Wen, W, Wojczynski, MK, Zhu, J, Borecki, IB, Bouchard, C, Cai, Q, Cooper, C, Dedoussis, GV, Deloukas, P, Ferrucci, L, Forouhi, NG, Hansen, T, Christiansen, L, Hofman, A, Johansson, I, Jørgensen, T, Karasawa, S, Khaw, K-T, Kim, M-K, Kristiansson, K, Li, H, Lin, X, Liu, Y, Lohman, KK, Long, J, Mikkilä, V, Mozaffarian, D, North, K, Pedersen, O, Raitakari, O, Rissanen, H, Tuomilehto, J, van der Schouw, YT, Uitterlinden, AG, Carola Zillikens, M, Franco, OH, Shyong Tai, E, Ou Shu, X, Siscovick, DS, Toft, U, Monique Verschuren, WM, Vollenweider, P, Wareham, NJ, Witteman, JCM, Zheng, W, Ridker, PM, Kang, JH, Liang, L, Jensen, MK, Curhan, GC, Pasquale, LR, Hunter, DJ, Mohlke, KL, Uusitupa, M, Adrienne Cupples, L, Rankinen, T, Orho-Melander, M, Wang, T, Chasman, DI, Franks, P, Sørensen, TIA, Hu, FB, Loos, RJF, Nettleton, JA & Qi, L 2014, 'FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals.', Human Molecular Genetics, vol. 23, no. 25, pp. 6961-6972. https://doi.org/10.1093/hmg/ddu411

APA

Qi, Q., Kilpeläinen, T. O., Downer, M. K., Tanaka, T., Smith, C. E., Sluijs, I., ... Qi, L. (2014). FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals. Human Molecular Genetics, 23(25), 6961-6972. https://doi.org/10.1093/hmg/ddu411

CBE

Qi Q, Kilpeläinen TO, Downer MK, Tanaka T, Smith CE, Sluijs I, Sonestedt E, Chu AY, Renström F, Lin X, Angquist LH, Huang J, Liu Z, Li Y, Asif Ali M, Xu M, Ahluwalia TS, Boer JMA, Chen P, Daimon M, Eriksson J, Perola M, Friedlander Y, Gao Y-T, Heppe DHM, Holloway JW, Houston DK, Kanoni S, Kim Y-M, Laaksonen MA, Jääskeläinen T, Lee NR, Lehtimäki T, Lemaitre RN, Lu W, Luben RN, Manichaikul A, Männistö S, Marques-Vidal P, Monda KL, Ngwa JS, Perusse L, van Rooij FJA, Xiang Y-B, Wen W, Wojczynski MK, Zhu J, Borecki IB, Bouchard C, Cai Q, Cooper C, Dedoussis GV, Deloukas P, Ferrucci L, Forouhi NG, Hansen T, Christiansen L, Hofman A, Johansson I, Jørgensen T, Karasawa S, Khaw K-T, Kim M-K, Kristiansson K, Li H, Lin X, Liu Y, Lohman KK, Long J, Mikkilä V, Mozaffarian D, North K, Pedersen O, Raitakari O, Rissanen H, Tuomilehto J, van der Schouw YT, Uitterlinden AG, Carola Zillikens M, Franco OH, Shyong Tai E, Ou Shu X, Siscovick DS, Toft U, Monique Verschuren WM, Vollenweider P, Wareham NJ, Witteman JCM, Zheng W, Ridker PM, Kang JH, Liang L, Jensen MK, Curhan GC, Pasquale LR, Hunter DJ, Mohlke KL, Uusitupa M, Adrienne Cupples L, Rankinen T, Orho-Melander M, Wang T, Chasman DI, Franks P, Sørensen TIA, Hu FB, Loos RJF, Nettleton JA, Qi L. 2014. FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals. Human Molecular Genetics. 23(25):6961-6972. https://doi.org/10.1093/hmg/ddu411

MLA

Vancouver

Author

Qi, Qibin ; Kilpeläinen, Tuomas O ; Downer, Mary K ; Tanaka, Toshiko ; Smith, Caren E ; Sluijs, Ivonne ; Sonestedt, Emily ; Chu, Audrey Y ; Renström, Frida ; Lin, Xiaochen ; Angquist, Lars H ; Huang, Jinyan ; Liu, Zhonghua ; Li, Yanping ; Asif Ali, Muhammad ; Xu, Min ; Ahluwalia, Tarunveer Singh ; Boer, Jolanda M A ; Chen, Peng ; Daimon, Makoto ; Eriksson, Johan ; Perola, Markus ; Friedlander, Yechiel ; Gao, Yu-Tang ; Heppe, Denise H M ; Holloway, John W ; Houston, Denise K ; Kanoni, Stavroula ; Kim, Yu-Mi ; Laaksonen, Maarit A ; Jääskeläinen, Tiina ; Lee, Nanette R ; Lehtimäki, Terho ; Lemaitre, Rozenn N ; Lu, Wei ; Luben, Robert N ; Manichaikul, Ani ; Männistö, Satu ; Marques-Vidal, Pedro ; Monda, Keri L ; Ngwa, Julius S ; Perusse, Louis ; van Rooij, Frank J A ; Xiang, Yong-Bing ; Wen, Wanqing ; Wojczynski, Mary K ; Zhu, Jingwen ; Borecki, Ingrid B ; Bouchard, Claude ; Cai, Qiuyin ; Cooper, Cyrus ; Dedoussis, George V ; Deloukas, Panos ; Ferrucci, Luigi ; Forouhi, Nita G ; Hansen, Torben ; Christiansen, Lene ; Hofman, Albert ; Johansson, Ingegerd ; Jørgensen, Torben ; Karasawa, Shigeru ; Khaw, Kay-Tee ; Kim, Mi-Kyung ; Kristiansson, Kati ; Li, Huaixing ; Lin, Xu ; Liu, Yongmei ; Lohman, Kurt K ; Long, Jirong ; Mikkilä, Vera ; Mozaffarian, Dariush ; North, Kari ; Pedersen, Oluf ; Raitakari, Olli ; Rissanen, Harri ; Tuomilehto, Jaakko ; van der Schouw, Yvonne T ; Uitterlinden, André G ; Carola Zillikens, M ; Franco, Oscar H ; Shyong Tai, E ; Ou Shu, Xiao ; Siscovick, David S ; Toft, Ulla ; Monique Verschuren, W M ; Vollenweider, Peter ; Wareham, Nicholas J ; Witteman, Jacqueline C M ; Zheng, Wei ; Ridker, Paul M ; Kang, Jae H ; Liang, Liming ; Jensen, Majken K ; Curhan, Gary C ; Pasquale, Louis R ; Hunter, David J ; Mohlke, Karen L ; Uusitupa, Matti ; Adrienne Cupples, L ; Rankinen, Tuomo ; Orho-Melander, Marju ; Wang, Tao ; Chasman, Daniel I ; Franks, Paul ; Sørensen, Thorkild I A ; Hu, Frank B ; Loos, Ruth J F ; Nettleton, Jennifer A ; Qi, Lu. / FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals. In: Human Molecular Genetics. 2014 ; Vol. 23, No. 25. pp. 6961-6972.

RIS

TY - JOUR

T1 - FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals.

AU - Qi, Qibin

AU - Kilpeläinen, Tuomas O

AU - Downer, Mary K

AU - Tanaka, Toshiko

AU - Smith, Caren E

AU - Sluijs, Ivonne

AU - Sonestedt, Emily

AU - Chu, Audrey Y

AU - Renström, Frida

AU - Lin, Xiaochen

AU - Angquist, Lars H

AU - Huang, Jinyan

AU - Liu, Zhonghua

AU - Li, Yanping

AU - Asif Ali, Muhammad

AU - Xu, Min

AU - Ahluwalia, Tarunveer Singh

AU - Boer, Jolanda M A

AU - Chen, Peng

AU - Daimon, Makoto

AU - Eriksson, Johan

AU - Perola, Markus

AU - Friedlander, Yechiel

AU - Gao, Yu-Tang

AU - Heppe, Denise H M

AU - Holloway, John W

AU - Houston, Denise K

AU - Kanoni, Stavroula

AU - Kim, Yu-Mi

AU - Laaksonen, Maarit A

AU - Jääskeläinen, Tiina

AU - Lee, Nanette R

AU - Lehtimäki, Terho

AU - Lemaitre, Rozenn N

AU - Lu, Wei

AU - Luben, Robert N

AU - Manichaikul, Ani

AU - Männistö, Satu

AU - Marques-Vidal, Pedro

AU - Monda, Keri L

AU - Ngwa, Julius S

AU - Perusse, Louis

AU - van Rooij, Frank J A

AU - Xiang, Yong-Bing

AU - Wen, Wanqing

AU - Wojczynski, Mary K

AU - Zhu, Jingwen

AU - Borecki, Ingrid B

AU - Bouchard, Claude

AU - Cai, Qiuyin

AU - Cooper, Cyrus

AU - Dedoussis, George V

AU - Deloukas, Panos

AU - Ferrucci, Luigi

AU - Forouhi, Nita G

AU - Hansen, Torben

AU - Christiansen, Lene

AU - Hofman, Albert

AU - Johansson, Ingegerd

AU - Jørgensen, Torben

AU - Karasawa, Shigeru

AU - Khaw, Kay-Tee

AU - Kim, Mi-Kyung

AU - Kristiansson, Kati

AU - Li, Huaixing

AU - Lin, Xu

AU - Liu, Yongmei

AU - Lohman, Kurt K

AU - Long, Jirong

AU - Mikkilä, Vera

AU - Mozaffarian, Dariush

AU - North, Kari

AU - Pedersen, Oluf

AU - Raitakari, Olli

AU - Rissanen, Harri

AU - Tuomilehto, Jaakko

AU - van der Schouw, Yvonne T

AU - Uitterlinden, André G

AU - Carola Zillikens, M

AU - Franco, Oscar H

AU - Shyong Tai, E

AU - Ou Shu, Xiao

AU - Siscovick, David S

AU - Toft, Ulla

AU - Monique Verschuren, W M

AU - Vollenweider, Peter

AU - Wareham, Nicholas J

AU - Witteman, Jacqueline C M

AU - Zheng, Wei

AU - Ridker, Paul M

AU - Kang, Jae H

AU - Liang, Liming

AU - Jensen, Majken K

AU - Curhan, Gary C

AU - Pasquale, Louis R

AU - Hunter, David J

AU - Mohlke, Karen L

AU - Uusitupa, Matti

AU - Adrienne Cupples, L

AU - Rankinen, Tuomo

AU - Orho-Melander, Marju

AU - Wang, Tao

AU - Chasman, Daniel I

AU - Franks, Paul

AU - Sørensen, Thorkild I A

AU - Hu, Frank B

AU - Loos, Ruth J F

AU - Nettleton, Jennifer A

AU - Qi, Lu

PY - 2014

Y1 - 2014

N2 - FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.

AB - FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.

U2 - 10.1093/hmg/ddu411

DO - 10.1093/hmg/ddu411

M3 - Article

VL - 23

SP - 6961

EP - 6972

JO - Human Molecular Genetics

T2 - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 25

ER -