Fully quantitative cardiovascular magnetic resonance myocardial perfusion ready for clinical use: A comparison between cardiovascular magnetic resonance imaging and positron emission tomography

Research output: Contribution to journalArticle

Abstract

Background: Recent studies have shown that quantification of myocardial perfusion (MP) at stress and myocardial perfusion reserve (MPR) offer additional diagnostic and prognostic information compared to qualitative and semi-quantitative assessment of myocardial perfusion distribution in patients with coronary artery disease (CAD). Technical advancements have enabled fully automatic quantification of MP using cardiovascular magnetic resonance (CMR) to be performed in-line in a clinical workflow. The aim of this study was to validate the use of the automated CMR perfusion mapping technique for quantification of MP using 13N-NH3 cardiac positron emission tomography (PET) as the reference method. Methods: Twenty-one patients with stable CAD were included in the study. All patients underwent adenosine stress and rest perfusion imaging with 13N-NH3 PET and a dual sequence, single contrast bolus CMR on the same day. Global and regional MP were quantified both at stress and rest using PET and CMR. Results: There was good agreement between global MP quantified by PET and CMR both at stress (-0.1 ± 0.5 ml/min/g) and at rest (0 ± 0.2 ml/min/g) with a strong correlation (r = 0.92, p < 0.001; y = 0.94× + 0.14). Furthermore, there was strong correlation between CMR and PET with regards to regional MP (r = 0.83, p < 0.001; y = 0.87× + 0.26) with a good agreement (-0.1 ± 0.6 ml/min/g). There was also a significant correlation between CMR and PET with regard to global and regional MPR (r = 0.69, p = 0.001 and r = 0.57, p < 0.001, respectively). Conclusions: There is good agreement between MP quantified by 13N-NH3 PET and dual sequence, single contrast bolus CMR in patients with stable CAD. Thus, CMR is viable in clinical practice for quantification of MP.

Details

Authors
Organisations
External organisations
  • National Heart Lung and Blood Institute
  • Skåne University Hospital
  • Aristotle University of Thessaloniki
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Radiology, Nuclear Medicine and Medical Imaging
  • Cardiac and Cardiovascular Systems

Keywords

  • Cardiac magnetic resonance, Myocardial perfusion, Myocardial perfusion reserve, Positron emission tomography
Original languageEnglish
Article number78
JournalJournal of Cardiovascular Magnetic Resonance
Volume19
Issue number1
Publication statusPublished - 2017 Oct 19
Publication categoryResearch
Peer-reviewedYes