Functional evaluation after rat sciatic nerve injury followed by hyperbaric oxygen treatment

Research output: Contribution to journalArticle

Standard

Functional evaluation after rat sciatic nerve injury followed by hyperbaric oxygen treatment. / Haapaniemi, T; Nishiura, Y; Dahlin, Lars.

In: Journal of the Peripheral Nervous System, Vol. 7, No. 3, 2002, p. 149-154.

Research output: Contribution to journalArticle

Harvard

APA

CBE

MLA

Vancouver

Author

RIS

TY - JOUR

T1 - Functional evaluation after rat sciatic nerve injury followed by hyperbaric oxygen treatment

AU - Haapaniemi, T

AU - Nishiura, Y

AU - Dahlin, Lars

PY - 2002

Y1 - 2002

N2 - Previous experimental studies have shown positive effects of hyperbaric oxygen treatment in the early regeneration phase in the first few days following a nerve injury. In this study, functional effects of hyperbaric oxygen treatment were studied in 2 series of rats after an injury to the sciatic nerve - a standardized crush injury and nerve transection and repair, respectively. Postoperatively the animals were treated with 100% oxygen at 2.5 atmospheres absolute pressure for 90 minutes and the treatment was employed twice daily for 7 days. The animals were evaluated with walking track analysis up to twice weekly. The experiments were terminated after 90 days when the tetanic force was measured in the tibial anterior and gastrocnemius muscles. No statistically significant differences were found in either of these tests. It is concluded that hyperbaric oxygen treatment, given in accordance with clinical protocols used in limb crush injuries and other peripheral conditions, was not effective in the restoration of gait or the muscular strength after 90 days in rats after these nerve injuries. This study does not support nerve crush injury or nerve transection and repair as indications for hyperbaric oxygen treatment.

AB - Previous experimental studies have shown positive effects of hyperbaric oxygen treatment in the early regeneration phase in the first few days following a nerve injury. In this study, functional effects of hyperbaric oxygen treatment were studied in 2 series of rats after an injury to the sciatic nerve - a standardized crush injury and nerve transection and repair, respectively. Postoperatively the animals were treated with 100% oxygen at 2.5 atmospheres absolute pressure for 90 minutes and the treatment was employed twice daily for 7 days. The animals were evaluated with walking track analysis up to twice weekly. The experiments were terminated after 90 days when the tetanic force was measured in the tibial anterior and gastrocnemius muscles. No statistically significant differences were found in either of these tests. It is concluded that hyperbaric oxygen treatment, given in accordance with clinical protocols used in limb crush injuries and other peripheral conditions, was not effective in the restoration of gait or the muscular strength after 90 days in rats after these nerve injuries. This study does not support nerve crush injury or nerve transection and repair as indications for hyperbaric oxygen treatment.

KW - tetanic force

KW - analysis

KW - walking track

KW - hyperbaric oxygenation

KW - nerve injury

KW - nerve repair

U2 - 10.1046/j.1529-8027.2002.02021.x

DO - 10.1046/j.1529-8027.2002.02021.x

M3 - Article

VL - 7

SP - 149

EP - 154

JO - Journal of the Peripheral Nervous System

JF - Journal of the Peripheral Nervous System

SN - 1085-9489

IS - 3

ER -