G protein-coupled estrogen receptor is apoptotic and correlates with increased distant disease-free survival of estrogen receptor-positive breast cancer patients.

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T1 - G protein-coupled estrogen receptor is apoptotic and correlates with increased distant disease-free survival of estrogen receptor-positive breast cancer patients.

AU - Broselid, Stefan

AU - Cheng, Benxu

AU - Sjöström, Martin

AU - Lövgren, Kristina

AU - Klug-De Santiago, Heather L P

AU - Belting, Mattias

AU - Jirström, Karin

AU - Malmström, Per

AU - Olde, Björn

AU - Bendahl, Pär-Ola

AU - Werner Hartman, Linda

AU - Fernö, Mårten

AU - Leeb-Lundberg, Fredrik

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Cancer Epidemiology (013007100), Oncology, MV (013035000), Department of Experimental Medical Science (013210000), Cardiology (013230026), Pathology, (Lund) (013030000), Drug Target Discovery (013212045)

PY - 2013

Y1 - 2013

N2 - G protein-coupled estrogen receptor 1 (GPER1), previously named GPR30, is a membrane receptor reported to mediate nongenomic estrogen responses. We investigated if GPER1 expression correlates with any clinicopathologic variables and distant disease-free survival (DDFS) in patients with breast cancer, if any prognostic impact of the receptor is dependent on estrogen receptor-α (ER-α) status, and if the receptor impacts apoptotic signaling in ER-positive breast cancer cells.

AB - G protein-coupled estrogen receptor 1 (GPER1), previously named GPR30, is a membrane receptor reported to mediate nongenomic estrogen responses. We investigated if GPER1 expression correlates with any clinicopathologic variables and distant disease-free survival (DDFS) in patients with breast cancer, if any prognostic impact of the receptor is dependent on estrogen receptor-α (ER-α) status, and if the receptor impacts apoptotic signaling in ER-positive breast cancer cells.

U2 - 10.1158/1078-0432.CCR-12-2376

DO - 10.1158/1078-0432.CCR-12-2376

M3 - Article

C2 - 23554355

VL - 19

SP - 1681

EP - 1692

JO - Clinical Cancer Research

JF - Clinical Cancer Research

SN - 1078-0432

IS - 7

ER -