GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families.

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Bibtex

@article{a8330bb0c77a4683b399e8fe5fef0b10,
title = "GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families.",
abstract = "Type 1 diabetes in Sardinia is very common in children, and we hypothesized that Latent Autoimmune Diabetes of Adult (LADA) might constitute a significant proportion of diabetes in adult Sardinian subjects. Since Type 2 diabetes is a familial disorder, we tested this hypothesis by investigating the prevalence of GAD65 and IA-2 autoantibodies (Ab) in Type 2 diabetes multiplex families of Sardinian ancestry enrolled in the Study Group for the Genetics of Diabetes in Sardinia. METHODS: A total of 684 individuals were ascertained from 252 Sardinian Type 2 diabetes multiplex families with 2.4 affected siblings per family comprising 190 families with two affected, 37 with three, 15 with four, 7 with five, and 3 with six, in addition to 80 unaffected siblings. Controls were household contacts representing 204 healthy spouses of affected siblings. Diagnosis was at 35-69 years of age and insulin was not given in the first 4 years after diagnosis. GAD65Ab and IA-2Ab were determined in standard r",
author = "Mario Maioli and G Tonolo and L Bekris and R Cirillo and D Schranz and E Cossu and M Ciccarese and {\AA}ke Lernmark and {Study Group for the Genetics of Diabetes in Sardinia (SGGDS}",
year = "2002",
doi = "10.1016/S0168-8227(01)00348-5",
language = "English",
volume = "56",
pages = "41--47",
journal = "Diabetes Research and Clinical Practice",
issn = "1872-8227",
publisher = "Elsevier",
number = "1",

}