GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families.

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GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families. / Maioli, Mario; Tonolo, G; Bekris, L; Cirillo, R; Schranz, D; Cossu, E; Ciccarese, M; Lernmark, Åke; Study Group for the Genetics of Diabetes in Sardinia (SGGDS.

In: Diabetes Research and Clinical Practice, Vol. 56, No. 1, 2002, p. 41-47.

Research output: Contribution to journalArticle

Harvard

Maioli, M, Tonolo, G, Bekris, L, Cirillo, R, Schranz, D, Cossu, E, Ciccarese, M, Lernmark, Å & Study Group for the Genetics of Diabetes in Sardinia (SGGDS 2002, 'GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families.', Diabetes Research and Clinical Practice, vol. 56, no. 1, pp. 41-47. https://doi.org/10.1016/S0168-8227(01)00348-5

APA

Maioli, M., Tonolo, G., Bekris, L., Cirillo, R., Schranz, D., Cossu, E., Ciccarese, M., Lernmark, Å., & Study Group for the Genetics of Diabetes in Sardinia (SGGDS (2002). GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families. Diabetes Research and Clinical Practice, 56(1), 41-47. https://doi.org/10.1016/S0168-8227(01)00348-5

CBE

Maioli M, Tonolo G, Bekris L, Cirillo R, Schranz D, Cossu E, Ciccarese M, Lernmark Å, Study Group for the Genetics of Diabetes in Sardinia (SGGDS. 2002. GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families. Diabetes Research and Clinical Practice. 56(1):41-47. https://doi.org/10.1016/S0168-8227(01)00348-5

MLA

Vancouver

Author

Maioli, Mario ; Tonolo, G ; Bekris, L ; Cirillo, R ; Schranz, D ; Cossu, E ; Ciccarese, M ; Lernmark, Åke ; Study Group for the Genetics of Diabetes in Sardinia (SGGDS. / GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families. In: Diabetes Research and Clinical Practice. 2002 ; Vol. 56, No. 1. pp. 41-47.

RIS

TY - JOUR

T1 - GAD65 and IA-2 autoantibodies are common in a subset of siblings of Sardinian Type 2 diabetes families.

AU - Maioli, Mario

AU - Tonolo, G

AU - Bekris, L

AU - Cirillo, R

AU - Schranz, D

AU - Cossu, E

AU - Ciccarese, M

AU - Lernmark, Åke

AU - Study Group for the Genetics of Diabetes in Sardinia (SGGDS

PY - 2002

Y1 - 2002

N2 - Type 1 diabetes in Sardinia is very common in children, and we hypothesized that Latent Autoimmune Diabetes of Adult (LADA) might constitute a significant proportion of diabetes in adult Sardinian subjects. Since Type 2 diabetes is a familial disorder, we tested this hypothesis by investigating the prevalence of GAD65 and IA-2 autoantibodies (Ab) in Type 2 diabetes multiplex families of Sardinian ancestry enrolled in the Study Group for the Genetics of Diabetes in Sardinia. METHODS: A total of 684 individuals were ascertained from 252 Sardinian Type 2 diabetes multiplex families with 2.4 affected siblings per family comprising 190 families with two affected, 37 with three, 15 with four, 7 with five, and 3 with six, in addition to 80 unaffected siblings. Controls were household contacts representing 204 healthy spouses of affected siblings. Diagnosis was at 35-69 years of age and insulin was not given in the first 4 years after diagnosis. GAD65Ab and IA-2Ab were determined in standard r

AB - Type 1 diabetes in Sardinia is very common in children, and we hypothesized that Latent Autoimmune Diabetes of Adult (LADA) might constitute a significant proportion of diabetes in adult Sardinian subjects. Since Type 2 diabetes is a familial disorder, we tested this hypothesis by investigating the prevalence of GAD65 and IA-2 autoantibodies (Ab) in Type 2 diabetes multiplex families of Sardinian ancestry enrolled in the Study Group for the Genetics of Diabetes in Sardinia. METHODS: A total of 684 individuals were ascertained from 252 Sardinian Type 2 diabetes multiplex families with 2.4 affected siblings per family comprising 190 families with two affected, 37 with three, 15 with four, 7 with five, and 3 with six, in addition to 80 unaffected siblings. Controls were household contacts representing 204 healthy spouses of affected siblings. Diagnosis was at 35-69 years of age and insulin was not given in the first 4 years after diagnosis. GAD65Ab and IA-2Ab were determined in standard r

U2 - 10.1016/S0168-8227(01)00348-5

DO - 10.1016/S0168-8227(01)00348-5

M3 - Article

VL - 56

SP - 41

EP - 47

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 1872-8227

IS - 1

ER -