Galectin-3 inhibits Schwann cell proliferation in cultured sciatic nerve

Research output: Contribution to journalArticle

Abstract

The production of galectin-3, a carbohydrate-binding mammalian lectin, is upregulated in Schwann cells after peripheral nerve injury in areas where Schwann cells proliferate. Here we tested if galectin-3 affected proliferation of Schwann cells in cultured sciatic nerve segments. Galectin-3 significantly decreased the number of bromodeoxyuridine-labelled Schwann cell nuclei. Neither lactose nor a synthetic inhibitor directed against the carbohydrate-binding region abolished the effects of galectin-3. In addition, a mutant galectin-3 unable to bind endogenous carbohydrates had similar effects as normal galectin-3. We conclude that galectin-3 reduces proliferation of Schwann cells in cultured sciatic nerve segments by a mechanism which is independent of its carbohydrate-binding moiety.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • Wallerian degeneration, sciatic, Schwann cells, proliferation, in vitro, galectin-3, injury, nerve
Original languageEnglish
Pages (from-to)669-673
JournalNeuroReport
Volume18
Issue number7
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes