Gastric bypass surgery, but not caloric restriction, decreases dipeptidyl peptidase 4 activity in obese patients with type 2 diabetes.

Research output: Contribution to journalArticle


The mechanism by which incretins and their effect on insulin secretion increase markedly following gastric bypass surgery (GBP) is not fully elucidated. We hypothesized that a decrease in the activity of dipeptidyl peptidase-4 (DPP-4), the enzyme which inactivates incretins, may explain the rise in incretin levels post-GBP. Fasting plasma DPP-4 activity was measured after 10 kg equivalent weight loss by GBP (n=16) or by caloric restriction (CR, n=14) in obese patients with type 2 diabetes. DPP-4 activity decreased after GBP by 11.6% (p=0.01), but not after CR. The increased peak GLP-1 and GIP response to oral glucose after GBP did not correlate with DPP-4 activity. The decrease in fasting plasma DPP-4 activity after GBP occurred by a mechanism independent of weight loss and did not relate to change in incretins concentrations. Whether the change in DPP-4 activity contributes to improved diabetes control after GBP remains therefore to be determined.


  • M Alam
  • B J Van der Schueren
  • Bo Ahrén
  • G C Wang
  • N J Swerdlow
  • S Arias
  • M Bose
  • P Gorroochurn
  • J Teixeira
  • J McGinty
  • B Laferrère
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Endocrinology and Diabetes


  • dipeptidyl peptidase inhibitor, gastric bypass, weight loss, GLP-1
Original languageEnglish
Pages (from-to)378-381
JournalDiabetes, Obesity and Metabolism
Issue number4
Publication statusPublished - 2011
Publication categoryResearch