Gelatin cryogels crosslinked with oxidized dextran and containing freshly formed hydroxyapatite as potential bone tissue-engineering scaffolds

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Abstract

Gelatin-based cryogels were prepared by using a novel crosslinker, oxidized dextran, which was synthesized and used in the study. The cryogels were also loaded with freshly formed hydroxyapatite (HA) particles. These cryogels are opaque, spongy and highly elastic and have a pore structure with large interconnected pores. They swell about 500% in aqueous media and within a few minutes reach their final swollen forms. The elastic moduli of HA-containing cryogels were 18.5 +/- 3.0 kPa, which is suitable for non-load-bearing bone tissue-engineering (TE) applications, especially for the craniofacial area. Copyright (c) 2012 John Wiley & Sons, Ltd.

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Subject classification (UKÄ) – MANDATORY

  • Industrial Biotechnology

Keywords

  • cryogelation, cryogel, scaffold, bone tissue engineering, gelatin, hydroxyapatite, oxidized dextran as crosslinker
Original languageEnglish
Pages (from-to)584-588
JournalJournal of Tissue Engineering and Regenerative Medicine
Volume7
Issue number7
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes