Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease

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Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. / Bomprezzi, R; Ringnér, Markus; Kim, S; Bittner, ML; Khan, J; Chen, YD; Elkahloun, A; Yu, AM; Bielekova, B; Meltzer, PS; Martin, R; McFarland, HF; Trent, JM.

In: Human Molecular Genetics, Vol. 12, No. 17, 2003, p. 2191-2199.

Research output: Contribution to journalArticle

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Bomprezzi, R, Ringnér, M, Kim, S, Bittner, ML, Khan, J, Chen, YD, Elkahloun, A, Yu, AM, Bielekova, B, Meltzer, PS, Martin, R, McFarland, HF & Trent, JM 2003, 'Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease', Human Molecular Genetics, vol. 12, no. 17, pp. 2191-2199. https://doi.org/10.1093/hmg/ddg221

APA

CBE

Bomprezzi R, Ringnér M, Kim S, Bittner ML, Khan J, Chen YD, Elkahloun A, Yu AM, Bielekova B, Meltzer PS, Martin R, McFarland HF, Trent JM. 2003. Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. Human Molecular Genetics. 12(17):2191-2199. https://doi.org/10.1093/hmg/ddg221

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Bomprezzi, R ; Ringnér, Markus ; Kim, S ; Bittner, ML ; Khan, J ; Chen, YD ; Elkahloun, A ; Yu, AM ; Bielekova, B ; Meltzer, PS ; Martin, R ; McFarland, HF ; Trent, JM. / Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease. In: Human Molecular Genetics. 2003 ; Vol. 12, No. 17. pp. 2191-2199.

RIS

TY - JOUR

T1 - Gene expression profile in multiple sclerosis patients and healthy controls: identifying pathways relevant to disease

AU - Bomprezzi, R

AU - Ringnér, Markus

AU - Kim, S

AU - Bittner, ML

AU - Khan, J

AU - Chen, YD

AU - Elkahloun, A

AU - Yu, AM

AU - Bielekova, B

AU - Meltzer, PS

AU - Martin, R

AU - McFarland, HF

AU - Trent, JM

PY - 2003

Y1 - 2003

N2 - Multiple sclerosis (MS) and other T cell-mediated autoimmune diseases develop in individuals carrying a complex susceptibility trait, probably following exposure to various environmental triggers. Owing to the presumed weak influence of single genes on disease predisposition and the recognized genetic heterogeneity of autoimmune disorders in humans, candidate gene searches in MS have been difficult. In an attempt to identify molecular markers indicative of disease status rather than susceptibility genes for MS, we show that gene expression profiling of peripheral blood mononuclear cells by cDNA microarrays can distinguish MS patients from healthy controls. Our findings support the concept that the activation of autoreactive T cells is of primary importance for this complex organ-specific disorder and prompt further investigations on gene expression in peripheral blood cells aimed at characterizing disease phenotypes.

AB - Multiple sclerosis (MS) and other T cell-mediated autoimmune diseases develop in individuals carrying a complex susceptibility trait, probably following exposure to various environmental triggers. Owing to the presumed weak influence of single genes on disease predisposition and the recognized genetic heterogeneity of autoimmune disorders in humans, candidate gene searches in MS have been difficult. In an attempt to identify molecular markers indicative of disease status rather than susceptibility genes for MS, we show that gene expression profiling of peripheral blood mononuclear cells by cDNA microarrays can distinguish MS patients from healthy controls. Our findings support the concept that the activation of autoreactive T cells is of primary importance for this complex organ-specific disorder and prompt further investigations on gene expression in peripheral blood cells aimed at characterizing disease phenotypes.

U2 - 10.1093/hmg/ddg221

DO - 10.1093/hmg/ddg221

M3 - Article

VL - 12

SP - 2191

EP - 2199

JO - Human Molecular Genetics

T2 - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 17

ER -