General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition

Research output: Contribution to journalArticle

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General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition. / Steffen, Annika; Huerta, Jose-Maria; Weiderpass, Elisabete; Bueno-de-Mesquita, H. B(As); May, Anne M.; Siersema, Peter D.; Kaaks, Rudolf; Neamat-Allah, Jasmine; Pala, Valeria; Panico, Salvatore; Saieva, Calogero; Tumino, Rosario; Naccarati, Alessio; Dorronsoro, Miren; Sanchez-Cantalejo, Emilio; Ardanaz, Eva; Ramon Quiros, J.; Ohlsson, Bodil; Johansson, Mattias; Wallner, Bengt; Overvad, Kim; Halkjaer, Jytte; Tjonneland, Anne; Fagherazzi, Guy; Racine, Antoine; Clavel-Chapelon, Francoise; Key, Tim J.; Khaw, Kay-Tee; Wareham, Nick; Lagiou, Pagona; Bamia, Christina; Trichopoulou, Antonia; Ferrari, Pietro; Freisling, Heinz; Lu, Yunxia; Riboli, Elio; Cross, Amanda J.; Gonzalez, Carlos A.; Boeing, Heiner.

In: International Journal of Cancer, Vol. 137, No. 3, 2015, p. 646-657.

Research output: Contribution to journalArticle

Harvard

Steffen, A, Huerta, J-M, Weiderpass, E, Bueno-de-Mesquita, HBA, May, AM, Siersema, PD, Kaaks, R, Neamat-Allah, J, Pala, V, Panico, S, Saieva, C, Tumino, R, Naccarati, A, Dorronsoro, M, Sanchez-Cantalejo, E, Ardanaz, E, Ramon Quiros, J, Ohlsson, B, Johansson, M, Wallner, B, Overvad, K, Halkjaer, J, Tjonneland, A, Fagherazzi, G, Racine, A, Clavel-Chapelon, F, Key, TJ, Khaw, K-T, Wareham, N, Lagiou, P, Bamia, C, Trichopoulou, A, Ferrari, P, Freisling, H, Lu, Y, Riboli, E, Cross, AJ, Gonzalez, CA & Boeing, H 2015, 'General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition', International Journal of Cancer, vol. 137, no. 3, pp. 646-657. https://doi.org/10.1002/ijc.29432

APA

Steffen, A., Huerta, J-M., Weiderpass, E., Bueno-de-Mesquita, H. BA., May, A. M., Siersema, P. D., Kaaks, R., Neamat-Allah, J., Pala, V., Panico, S., Saieva, C., Tumino, R., Naccarati, A., Dorronsoro, M., Sanchez-Cantalejo, E., Ardanaz, E., Ramon Quiros, J., Ohlsson, B., Johansson, M., ... Boeing, H. (2015). General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer, 137(3), 646-657. https://doi.org/10.1002/ijc.29432

CBE

Steffen A, Huerta J-M, Weiderpass E, Bueno-de-Mesquita HBA, May AM, Siersema PD, Kaaks R, Neamat-Allah J, Pala V, Panico S, Saieva C, Tumino R, Naccarati A, Dorronsoro M, Sanchez-Cantalejo E, Ardanaz E, Ramon Quiros J, Ohlsson B, Johansson M, Wallner B, Overvad K, Halkjaer J, Tjonneland A, Fagherazzi G, Racine A, Clavel-Chapelon F, Key TJ, Khaw K-T, Wareham N, Lagiou P, Bamia C, Trichopoulou A, Ferrari P, Freisling H, Lu Y, Riboli E, Cross AJ, Gonzalez CA, Boeing H. 2015. General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition. International Journal of Cancer. 137(3):646-657. https://doi.org/10.1002/ijc.29432

MLA

Vancouver

Author

Steffen, Annika ; Huerta, Jose-Maria ; Weiderpass, Elisabete ; Bueno-de-Mesquita, H. B(As) ; May, Anne M. ; Siersema, Peter D. ; Kaaks, Rudolf ; Neamat-Allah, Jasmine ; Pala, Valeria ; Panico, Salvatore ; Saieva, Calogero ; Tumino, Rosario ; Naccarati, Alessio ; Dorronsoro, Miren ; Sanchez-Cantalejo, Emilio ; Ardanaz, Eva ; Ramon Quiros, J. ; Ohlsson, Bodil ; Johansson, Mattias ; Wallner, Bengt ; Overvad, Kim ; Halkjaer, Jytte ; Tjonneland, Anne ; Fagherazzi, Guy ; Racine, Antoine ; Clavel-Chapelon, Francoise ; Key, Tim J. ; Khaw, Kay-Tee ; Wareham, Nick ; Lagiou, Pagona ; Bamia, Christina ; Trichopoulou, Antonia ; Ferrari, Pietro ; Freisling, Heinz ; Lu, Yunxia ; Riboli, Elio ; Cross, Amanda J. ; Gonzalez, Carlos A. ; Boeing, Heiner. / General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition. In: International Journal of Cancer. 2015 ; Vol. 137, No. 3. pp. 646-657.

RIS

TY - JOUR

T1 - General and abdominal obesity and risk of esophageal and gastric adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition

AU - Steffen, Annika

AU - Huerta, Jose-Maria

AU - Weiderpass, Elisabete

AU - Bueno-de-Mesquita, H. B(As)

AU - May, Anne M.

AU - Siersema, Peter D.

AU - Kaaks, Rudolf

AU - Neamat-Allah, Jasmine

AU - Pala, Valeria

AU - Panico, Salvatore

AU - Saieva, Calogero

AU - Tumino, Rosario

AU - Naccarati, Alessio

AU - Dorronsoro, Miren

AU - Sanchez-Cantalejo, Emilio

AU - Ardanaz, Eva

AU - Ramon Quiros, J.

AU - Ohlsson, Bodil

AU - Johansson, Mattias

AU - Wallner, Bengt

AU - Overvad, Kim

AU - Halkjaer, Jytte

AU - Tjonneland, Anne

AU - Fagherazzi, Guy

AU - Racine, Antoine

AU - Clavel-Chapelon, Francoise

AU - Key, Tim J.

AU - Khaw, Kay-Tee

AU - Wareham, Nick

AU - Lagiou, Pagona

AU - Bamia, Christina

AU - Trichopoulou, Antonia

AU - Ferrari, Pietro

AU - Freisling, Heinz

AU - Lu, Yunxia

AU - Riboli, Elio

AU - Cross, Amanda J.

AU - Gonzalez, Carlos A.

AU - Boeing, Heiner

PY - 2015

Y1 - 2015

N2 - General obesity, as reflected by BMI, is an established risk factor for esophageal adenocarcinoma (EAC), a suspected risk factor for gastric cardia adenocarcinoma (GCC) and appears unrelated to gastric non-cardia adenocarcinoma (GNCC). How abdominal obesity, as commonly measured by waist circumference (WC), relates to these cancers remains largely unexplored. Using measured anthropometric data from 391,456 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC) study and 11 years of follow-up, we comprehensively assessed the association of anthropometric measures with risk of EAC, GCC and GNCC using multivariable proportional hazards regression. One hundred twenty-four incident EAC, 193 GCC and 224 GNCC were accrued. After mutual adjustment, BMI was unrelated to EAC, while WC showed a strong positive association (highest vs. lowest quintile HR=1.19; 95% CI, 0.63-2.22 and HR=3.76; 1.72-8.22, respectively). Hip circumference (HC) was inversely related to EAC after controlling for WC, while WC remained positively associated (HR=0.35; 0.18-0.68, and HR=4.10; 1.94-8.63, respectively). BMI was not associated with GCC or GNCC. WC was related to higher risks of GCC after adjustment for BMI and more strongly after adjustment for HC (highest vs. lowest quintile HR=1.91; 1.09-3.37, and HR=2.23; 1.28-3.90, respectively). Our study demonstrates that abdominal, rather than general, obesity is an indisputable risk factor for EAC and also provides evidence for a protective effect of gluteofemoral (subcutaneous) adipose tissue in EAC. Our study further shows that general obesity is not a risk factor for GCC and GNCC, while the role of abdominal obesity in GCC needs further investigation. What's new? While mainly general obesity, as measured by body mass index, has been investigated in relation to gastric and esophageal cancer, the effect of a large waist on these cancer sites is unknown. In this article, the authors report results of extensive analysis of measured anthropometry, including measures of general (BMI) and abdominal obesity (waist circumference), collected by the European Prospective Investigation into Cancer and Nutrition (EPIC). They show that general obesity is not a risk factor for esophageal and gastric cancer, while waist circumference strongly increases risk of esophageal cancer and may potentially be related to gastric cardia cancer.

AB - General obesity, as reflected by BMI, is an established risk factor for esophageal adenocarcinoma (EAC), a suspected risk factor for gastric cardia adenocarcinoma (GCC) and appears unrelated to gastric non-cardia adenocarcinoma (GNCC). How abdominal obesity, as commonly measured by waist circumference (WC), relates to these cancers remains largely unexplored. Using measured anthropometric data from 391,456 individuals from the European Prospective Investigation into Cancer and Nutrition (EPIC) study and 11 years of follow-up, we comprehensively assessed the association of anthropometric measures with risk of EAC, GCC and GNCC using multivariable proportional hazards regression. One hundred twenty-four incident EAC, 193 GCC and 224 GNCC were accrued. After mutual adjustment, BMI was unrelated to EAC, while WC showed a strong positive association (highest vs. lowest quintile HR=1.19; 95% CI, 0.63-2.22 and HR=3.76; 1.72-8.22, respectively). Hip circumference (HC) was inversely related to EAC after controlling for WC, while WC remained positively associated (HR=0.35; 0.18-0.68, and HR=4.10; 1.94-8.63, respectively). BMI was not associated with GCC or GNCC. WC was related to higher risks of GCC after adjustment for BMI and more strongly after adjustment for HC (highest vs. lowest quintile HR=1.91; 1.09-3.37, and HR=2.23; 1.28-3.90, respectively). Our study demonstrates that abdominal, rather than general, obesity is an indisputable risk factor for EAC and also provides evidence for a protective effect of gluteofemoral (subcutaneous) adipose tissue in EAC. Our study further shows that general obesity is not a risk factor for GCC and GNCC, while the role of abdominal obesity in GCC needs further investigation. What's new? While mainly general obesity, as measured by body mass index, has been investigated in relation to gastric and esophageal cancer, the effect of a large waist on these cancer sites is unknown. In this article, the authors report results of extensive analysis of measured anthropometry, including measures of general (BMI) and abdominal obesity (waist circumference), collected by the European Prospective Investigation into Cancer and Nutrition (EPIC). They show that general obesity is not a risk factor for esophageal and gastric cancer, while waist circumference strongly increases risk of esophageal cancer and may potentially be related to gastric cardia cancer.

KW - general obesity

KW - abdominal obesity

KW - body mass index

KW - waist

KW - circumference

KW - gastric cancer

KW - esophageal cancer

U2 - 10.1002/ijc.29432

DO - 10.1002/ijc.29432

M3 - Article

C2 - 25598323

VL - 137

SP - 646

EP - 657

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 3

ER -