Generalized rank tests for replicated microarray data

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Abstract

Gene expression data from microarray experiments have been studied using several statistical models. Significance Analysis of Microarrays (SAM), for example, has proved to be useful in analyzing microarray data. In the spirit of the SAM procedures, we develop permutation based rank-tests for generalized Wilcoxon ranksum test for two-group comparisons of replicated microarray data. Also, for microarray experiments with randomized block design, we consider generalized signed rank test. The statistical analysis software package is written in R and is freely available in a package.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems

Keywords

  • blocked comparisons, rank tests, permutation tests
Original languageEnglish
JournalStatistical Applications in Genetics and Molecular Biology
Volume4
Issue number1
Publication statusPublished - 2005
Publication categoryResearch
Peer-reviewedYes