Generation of a human induced pluripotent stem cell line (CSC-42) from a patient with sporadic form of Parkinson's disease

Research output: Contribution to journalArticle

Abstract

Skin fibroblasts were collected from a 44-year-old patient with sporadic case of Parkinson's disease (PD). The non-integrating Sendai virus vector encoding OCT3/4, SOX2, c-MYC and KLF4 was used to reprogram fibroblasts into induced pluripotent stem cells (iPSCs). Generated iPSCs had normal karyotypes, expressed common stem cell markers, and were capable of differentiating into all three germ layers. Generated line could be used for PD modeling to understand the mechanisms that influence the disorder.

Details

Authors
Organisations
External organisations
  • University of Minho
  • Istituto Ortopedico Gaetano Pini
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
Original languageEnglish
Pages (from-to)78-81
Number of pages4
JournalStem Cell Research
Volume27
Publication statusPublished - 2018 Mar 1
Publication categoryResearch
Peer-reviewedYes